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Moxifloxacin

Medication fluoroquinolone antibiotic antibiotic
Aka: Avelox, Vigamox
Brands seen in Singapore: Avelox, Moloxin, Moxifloxacin-Teva, Floxsafe, Vigamox
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for bacterial infections — your doctor decides
When to take
Once every 24 hours · eye drops usually 3 times a day
Take with
Water · tablet swallowed whole, meals do not matter
Pros & cons
Pros
  • SG label: one 400 mg tablet a day, food independent
  • No dose change needed in kidney impairment (labels)
  • Eye drops also registered in SG (vigamox)
Cons
  • Boxed warning: tendon, nerve and CNS reactions
  • Qt prolongation — heart conditions are contraindicated
  • SG label: contraindicated under 18 and in pregnancy
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset; filtered locally for moxifloxacin) · read 2026-08-27
    what it says
    “Forensicclassification = 'Prescription Only' for all 15 moxifloxacin rows (8 oral 400 mg tablets, 5 infusions, 2 eye drops) — e.g. SIN11351P AVELOX TABLET 400 mg; SIN15579P MOLOXIN FILM-COATED TABLETS 400MG; SIN12614P VIGAMOX OPHTHALMIC SOLUTION 0.5%”
  2. MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], product information · read 2026-08-27
    what it says
    “MOXIFLOXACIN HCL EQV MOXIFLOXACIN - 400 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA”
  3. MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], indications · read 2026-08-27
    what it says
    “Avelox 400 mg film-coated tablets are indicated for the treatment of the following bacterial infections caused by susceptible strains: Respiratory tract infections … Uncomplicated skin and skin structure infections … Mild to moderate pelvic inflammatory disease”
  4. MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], dosage regimen · read 2026-08-27
    what it says
    “The recommended dose for Avelox is 400 mg once daily (1 film coated tablet) for the above mentioned indications and should not be exceeded.”
  5. MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], method of administration · read 2026-08-27
    what it says
    “The film-coated tablet should be swallowed whole with sufficient liquid and may be taken independent of meals.”
  6. MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], contraindications · read 2026-08-27
    what it says
    “Known hypersensitivity to moxifloxacin or other quinolones … Pregnancy and lactation. Patients below 18 years of age. Patients with a history of tendon disease/disorder related to quinolone treatment … Congenital or documented acquired QT prolongation”
  7. MOH National Drug Formulary — VIGAMOX OPHTHALMIC SOLUTION 0.5% [SIN12614P], indications · read 2026-08-27
    what it says
    “VIGAMOX solution is indicated for the treatment of bacterial conjunctivitis, blepharitis, dacryocystitis, hordeolum, tarsadenitis, keratitis (including corneal ulcer) caused by susceptible strains, as well as preoperative and postoperative prophylaxis.”
  8. MOH National Drug Formulary — VIGAMOX [SIN12614P], posology · read 2026-08-27
    what it says
    “Usually instill one drop in the affected eye 3 times a day … For preoperative and postoperative prophylaxis: … one drop … 5 times per day for 2 days before operation”
  9. MOH National Drug Formulary — VIGAMOX [SIN12614P], special populations · read 2026-08-27
    what it says
    “Dose adjustment of moxifloxacin does not appear to be necessary in patients with renal dysfunction … not necessary in patients with mild to moderate hepatic impairment.”
  10. FDA DailyMed — Moxifloxacin hydrochloride tablets (A-S Medication Solutions), Dosage and Administration, eff. 2024-09-18 · read 2026-08-27
    what it says
    “The dose of moxifloxacin is 400 mg (orally) once every 24 hours. The duration of therapy depends on the type of infection … No dosage adjustment in patients with renal or hepatic impairment.”
  11. FDA DailyMed — Moxifloxacin hydrochloride tablets, Boxed Warning · read 2026-08-27
    what it says
    “Fluoroquinolones, including moxifloxacin hydrochloride, have been associated with disabling and potentially irreversible serious adverse reactions … Tendinitis and tendon rupture … Peripheral neuropathy … Central nervous system effects … may exacerbate muscle weakness in patients with myasthenia gravis”
  12. FDA DailyMed — Moxifloxacin hydrochloride tablets, Drug Interactions · read 2026-08-27
    what it says
    “antacids, sucralfate, multivitamins Decreased moxifloxacin hydrochloride absorption. Take moxifloxacin tablet at least 4 hours before or 8 hours after these products. Warfarin Anticoagulant effect enhanced … Class IA and Class III antiarrhythmics: Proarrhythmic effect may be enhanced. Avoid concomitant use.”
  13. FDA DailyMed — Moxifloxacin hydrochloride tablets, Drug Interactions (antidiabetic agents) · read 2026-08-27
    what it says
    “Antidiabetic agents Carefully monitor blood glucose. (5.12, 7.3)”
  14. FDA DailyMed — Moxifloxacin hydrochloride tablets, Adverse Reactions · read 2026-08-27
    what it says
    “Exacerbation of Myasthenia Gravis … QT Prolongation … Risk of Aortic Aneurysm and Dissection … Clostridioides difficile-Associated Diarrhea … Blood Glucose Disturbances … Photosensitivity”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.