{"ok":true,"entry":{"slug":"moxifloxacin","kind":"medication","name":"moxifloxacin","aliases":["Avelox","Vigamox"],"brands_sg":["Avelox","Moloxin","Moxifloxacin-Teva","Floxsafe","Vigamox"],"class":"fluoroquinolone antibiotic","tags":["antibiotic"],"use_for":"prescribed for bacterial infections — your doctor decides","use_after":"once every 24 hours · eye drops usually 3 times a day","use_duration":null,"take_with":"water · tablet swallowed whole, meals do not matter","pros":["sg label: one 400 mg tablet a day, food independent","no dose change needed in kidney impairment (labels)","eye drops also registered in sg (vigamox)"],"cons":["boxed warning: tendon, nerve and cns reactions","qt prolongation — heart conditions are contraindicated","sg label: contraindicated under 18 and in pregnancy"],"dose_note":"the singapore avelox tablet insert (SIN11351P) states \"The recommended dose for Avelox is 400 mg once daily (1 film coated tablet) for the above mentioned indications and should not be exceeded\" — an explicit ceiling, matched by the us label (\"The dose of moxifloxacin is 400 mg (orally) once every 24 hours\"). for the eye drops, the singapore vigamox insert (SIN12614P) says \"Usually instill one drop in the affected eye 3 times a day\", with the highest listed frequency being \"one drop in the affected eye 5 times per day for 2 days before operation\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["quinolone allergy or past tendon trouble on a quinolone","qt problems, low potassium, slow heart rate, heart failure","pregnancy, breastfeeding and under-18s — sg label excludes","myasthenia gravis — us boxed warning: avoid"],"clashes":[{"src":["fda_moxi_int"],"note":"us label: moxifloxacin at least 4 h before or 8 h after these products","with":"antacids, sucralfate, multivitamins, iron"},{"src":["fda_moxi_int"],"note":"us label: anticoagulant effect enhanced — inr and bleeding monitored","with":"warfarin"},{"src":["fda_moxi_int"],"note":"us label: proarrhythmic effect may be enhanced — concomitant use avoided","with":"class ia and class iii antiarrhythmics"},{"src":["ndf_avelox_contra"],"note":"sg label: avelox should not be used concurrently with other drugs that prolong the qt interval","with":"other qt-prolonging medicines"},{"src":["fda_moxi_int2"],"note":"us label: blood glucose carefully monitored","with":"diabetes medicines"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset; filtered locally for moxifloxacin)","quote":"Forensicclassification = 'Prescription Only' for all 15 moxifloxacin rows (8 oral 400 mg tablets, 5 infusions, 2 eye drops) — e.g. SIN11351P AVELOX TABLET 400 mg; SIN15579P MOLOXIN FILM-COATED TABLETS 400MG; SIN12614P VIGAMOX OPHTHALMIC SOLUTION 0.5%","accessed":"2026-08-27"},{"id":"ndf_avelox_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11351p/","label":"MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], product information","quote":"MOXIFLOXACIN HCL EQV MOXIFLOXACIN - 400 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_avelox_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11351p/","label":"MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], indications","quote":"Avelox 400 mg film-coated tablets are indicated for the treatment of the following bacterial infections caused by susceptible strains: Respiratory tract infections … Uncomplicated skin and skin structure infections … Mild to moderate pelvic inflammatory disease","accessed":"2026-08-27"},{"id":"ndf_avelox_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11351p/","label":"MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], dosage regimen","quote":"The recommended dose for Avelox is 400 mg once daily (1 film coated tablet) for the above mentioned indications and should not be exceeded.","accessed":"2026-08-27"},{"id":"ndf_avelox_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11351p/","label":"MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], method of administration","quote":"The film-coated tablet should be swallowed whole with sufficient liquid and may be taken independent of meals.","accessed":"2026-08-27"},{"id":"ndf_avelox_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11351p/","label":"MOH National Drug Formulary — AVELOX TABLET 400 MG [SIN11351P], contraindications","quote":"Known hypersensitivity to moxifloxacin or other quinolones … Pregnancy and lactation. Patients below 18 years of age. Patients with a history of tendon disease/disorder related to quinolone treatment … Congenital or documented acquired QT prolongation","accessed":"2026-08-27"},{"id":"ndf_vigamox_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12614p/","label":"MOH National Drug Formulary — VIGAMOX OPHTHALMIC SOLUTION 0.5% [SIN12614P], indications","quote":"VIGAMOX solution is indicated for the treatment of bacterial conjunctivitis, blepharitis, dacryocystitis, hordeolum, tarsadenitis, keratitis (including corneal ulcer) caused by susceptible strains, as well as preoperative and postoperative prophylaxis.","accessed":"2026-08-27"},{"id":"ndf_vigamox_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12614p/","label":"MOH National Drug Formulary — VIGAMOX [SIN12614P], posology","quote":"Usually instill one drop in the affected eye 3 times a day … For preoperative and postoperative prophylaxis: … one drop … 5 times per day for 2 days before operation","accessed":"2026-08-27"},{"id":"ndf_vigamox_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12614p/","label":"MOH National Drug Formulary — VIGAMOX [SIN12614P], special populations","quote":"Dose adjustment of moxifloxacin does not appear to be necessary in patients with renal dysfunction … not necessary in patients with mild to moderate hepatic impairment.","accessed":"2026-08-27"},{"id":"fda_moxi_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02c29e8e-8346-4e28-b7fc-2f4cb61ad37d","label":"FDA DailyMed — Moxifloxacin hydrochloride tablets (A-S Medication Solutions), Dosage and Administration, eff. 2024-09-18","quote":"The dose of moxifloxacin is 400 mg (orally) once every 24 hours. The duration of therapy depends on the type of infection … No dosage adjustment in patients with renal or hepatic impairment.","accessed":"2026-08-27"},{"id":"fda_moxi_boxed","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02c29e8e-8346-4e28-b7fc-2f4cb61ad37d","label":"FDA DailyMed — Moxifloxacin hydrochloride tablets, Boxed Warning","quote":"Fluoroquinolones, including moxifloxacin hydrochloride, have been associated with disabling and potentially irreversible serious adverse reactions … Tendinitis and tendon rupture … Peripheral neuropathy … Central nervous system effects … may exacerbate muscle weakness in patients with myasthenia gravis","accessed":"2026-08-27"},{"id":"fda_moxi_int","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02c29e8e-8346-4e28-b7fc-2f4cb61ad37d","label":"FDA DailyMed — Moxifloxacin hydrochloride tablets, Drug Interactions","quote":"antacids, sucralfate, multivitamins Decreased moxifloxacin hydrochloride absorption. Take moxifloxacin tablet at least 4 hours before or 8 hours after these products. Warfarin Anticoagulant effect enhanced … Class IA and Class III antiarrhythmics: Proarrhythmic effect may be enhanced. Avoid concomitant use.","accessed":"2026-08-27"},{"id":"fda_moxi_int2","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02c29e8e-8346-4e28-b7fc-2f4cb61ad37d","label":"FDA DailyMed — Moxifloxacin hydrochloride tablets, Drug Interactions (antidiabetic agents)","quote":"Antidiabetic agents Carefully monitor blood glucose. (5.12, 7.3)","accessed":"2026-08-27"},{"id":"fda_moxi_adverse","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=02c29e8e-8346-4e28-b7fc-2f4cb61ad37d","label":"FDA DailyMed — Moxifloxacin hydrochloride tablets, Adverse Reactions","quote":"Exacerbation of Myasthenia Gravis … QT Prolongation … Risk of Aortic Aneurysm and Dissection … Clostridioides difficile-Associated Diarrhea … Blood Glucose Disturbances … Photosensitivity","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}