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Mirtazapine

Medication noradrenergic/serotonergic antidepressant mental health
Aka: Remeron
Brands seen in Singapore: Remeron SolTab, Apo-Mirtazapine, Mirtazapine Sandoz
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
HealthHub: symptoms of depression such as low mood
When to take
SG label: usually one night-time dose before bed
Take with
HealthHub: with or without food · alcohol adds sleepiness
Pros & cons
Pros
  • SG label: suitable for once-daily night-time dosing
  • HealthHub: orodispersible tablets need no water
  • SG label: effect generally begins after 1–2 weeks
Cons
  • HealthHub: drowsiness, appetite rise, weight gain
  • HealthHub: dry mouth, constipation, dizziness
  • HealthHub: abrupt stopping can cause dizziness, nausea
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 5 registered mirtazapine products read Forensicclassification 'Prescription Only' — SIN12526P REMERON SOLTAB 15 mg · SIN12527P REMERON SOLTAB 30 mg · SIN14012P APO-MIRTAZAPINE TABLET 30MG · SIN13643P Mirtazapine Sandoz Orodispersible Tablets 15mg”
  2. HealthHub (National Medication Information workgroup, SG) — Mirtazapine: what is this medication for · read 2026-08-27
    what it says
    “Mirtazapine belongs to a class of medications known as Noradrenergic, Specific Serotonergic Antidepressants (NaSSA). It is used to treat symptoms of depression such as: Feeling sad; Loss of interest in usual activities; Feeling hopeless or useless”
  3. HealthHub — Mirtazapine: how should I take this medication · read 2026-08-27
    what it says
    “Mirtazapine may be taken with or without food. Mirtazapine is available as orodispersible tablets. This means that these tablets dissolve when you put them in your mouth and can be swallowed without water.”
  4. HealthHub — Mirtazapine: stopping the medication · read 2026-08-27
    what it says
    “You may experience unpleasant effects such as dizziness, headache, difficulty sleeping, irritability, and nausea if you suddenly stop taking the medication on your own.”
  5. HealthHub — Mirtazapine: common side effects · read 2026-08-27
    what it says
    “Drowsiness or feeling tired … Increase in appetite, weight gain … Dry mouth … Constipation … Dizziness … Headache. Most of the side effects listed here will improve with time.”
  6. HealthHub — Mirtazapine: important warning for patients under 25 · read 2026-08-27
    what it says
    “The following changes have been observed in some patients particularly below the age of 25 years taking this medication: New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour”
  7. HealthHub — Mirtazapine: what precautions should I take · read 2026-08-27
    what it says
    “You have or have ever had: Other drug allergies … Heart, kidney or liver disease; Medical conditions such as seizures (fits), Parkinson's disease, urinary problems, diabetes, high cholesterol, low blood pressure … bipolar disorder, abnormally high or excited mood (mania)”
  8. HealthHub — Mirtazapine: precautions on other medicines and supplements · read 2026-08-27
    what it says
    “You are taking any other medications (including those that can be bought without a prescription), supplements such as St John's Wort, traditional medications and herbal remedies. Some of them may affect how this medication works”
  9. HealthHub — Mirtazapine: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol while taking Mirtazapine as it can worsen the symptoms of your depression and cause excessive sleepiness.”
  10. Singapore National Drug Formulary (HSA/MOH) — REMERON SOLTAB 30 MG [SIN12527P], section 4.2 Posology (adults) · read 2026-08-27
    what it says
    “Treatment should begin with 15 mg daily … The effective daily dose is usually between 15 and 45 mg (the dose should be taken at night) … the dose can be increased up to the maximum dose.”
  11. Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], half-life and timing · read 2026-08-27
    what it says
    “Mirtazapine has an elimination half-life of 20–40 hours and therefore Remeron is suitable for once daily administration. It should be taken preferably as a single night-time dose before going to bed.”
  12. Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], onset of effect · read 2026-08-27
    what it says
    “Mirtazapine begins to exert its effect in general after 1–2 weeks of treatment. Treatment with an adequate dose should result in a positive response within 2–4 weeks.”
  13. Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], children and adolescents · read 2026-08-27
    what it says
    “Remeron should not be used in children and adolescents under the age of 18 years … as efficacy was not demonstrated in two short-term clinical trials and because of safety concerns”
  14. Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], section 4.3 Contraindications · read 2026-08-27
    what it says
    “Hypersensitivity to the active substance or to any of the excipients. Concomitant use of mirtazapine with monoamine oxidase (MAO) inhibitors”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.