{"ok":true,"entry":{"slug":"mirtazapine","kind":"medication","name":"mirtazapine","aliases":["Remeron"],"brands_sg":["Remeron SolTab","Apo-Mirtazapine","Mirtazapine Sandoz"],"class":"noradrenergic/serotonergic antidepressant","tags":["mental-health"],"use_for":"healthhub: symptoms of depression such as low mood","use_after":"sg label: usually one night-time dose before bed","use_duration":null,"take_with":"healthhub: with or without food · alcohol adds sleepiness","pros":["sg label: suitable for once-daily night-time dosing","healthhub: orodispersible tablets need no water","sg label: effect generally begins after 1–2 weeks"],"cons":["healthhub: drowsiness, appetite rise, weight gain","healthhub: dry mouth, constipation, dizziness","healthhub: abrupt stopping can cause dizziness, nausea"],"dose_note":"the singapore label for remeron soltab states 'Treatment should begin with 15 mg daily … The effective daily dose is usually between 15 and 45 mg (the dose should be taken at night)' and that with an insufficient response 'the dose can be increased up to the maximum dose'. 45 mg a day is the top of that stated range; the sg-registered strengths are 15 mg and 30 mg orodispersible tablets. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["healthhub: under 25 — new or worsening self-harm thoughts reported","sg label: not for under-18s, efficacy was not demonstrated","healthhub: heart, kidney or liver disease","healthhub: seizures, parkinson's disease, bipolar disorder or mania"],"clashes":[{"src":["ndf_rem_ci"],"note":"concomitant use is a contraindication on the sg remeron label","with":"monoamine oxidase (mao) inhibitors"},{"src":["hh_mir_avoid"],"food":true,"note":"healthhub: can worsen depression symptoms and cause excessive sleepiness","with":"alcohol"},{"src":["hh_mir_supp"],"note":"healthhub: some may affect how it works or cause serious drug interactions","with":"st john's wort and other supplements"},{"src":["hh_mir_prec"],"note":"healthhub asks that these be declared before starting","with":"other mood medicines used in the past 2 weeks"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 5 registered mirtazapine products read Forensicclassification 'Prescription Only' — SIN12526P REMERON SOLTAB 15 mg · SIN12527P REMERON SOLTAB 30 mg · SIN14012P APO-MIRTAZAPINE TABLET 30MG · SIN13643P Mirtazapine Sandoz Orodispersible Tablets 15mg","accessed":"2026-08-27"},{"id":"hh_mir_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub (National Medication Information workgroup, SG) — Mirtazapine: what is this medication for","quote":"Mirtazapine belongs to a class of medications known as Noradrenergic, Specific Serotonergic Antidepressants (NaSSA). It is used to treat symptoms of depression such as: Feeling sad; Loss of interest in usual activities; Feeling hopeless or useless","accessed":"2026-08-27"},{"id":"hh_mir_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: how should I take this medication","quote":"Mirtazapine may be taken with or without food. Mirtazapine is available as orodispersible tablets. This means that these tablets dissolve when you put them in your mouth and can be swallowed without water.","accessed":"2026-08-27"},{"id":"hh_mir_stop","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: stopping the medication","quote":"You may experience unpleasant effects such as dizziness, headache, difficulty sleeping, irritability, and nausea if you suddenly stop taking the medication on your own.","accessed":"2026-08-27"},{"id":"hh_mir_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: common side effects","quote":"Drowsiness or feeling tired … Increase in appetite, weight gain … Dry mouth … Constipation … Dizziness … Headache. Most of the side effects listed here will improve with time.","accessed":"2026-08-27"},{"id":"hh_mir_young","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: important warning for patients under 25","quote":"The following changes have been observed in some patients particularly below the age of 25 years taking this medication: New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"hh_mir_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: what precautions should I take","quote":"You have or have ever had: Other drug allergies … Heart, kidney or liver disease; Medical conditions such as seizures (fits), Parkinson's disease, urinary problems, diabetes, high cholesterol, low blood pressure … bipolar disorder, abnormally high or excited mood (mania)","accessed":"2026-08-27"},{"id":"hh_mir_supp","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: precautions on other medicines and supplements","quote":"You are taking any other medications (including those that can be bought without a prescription), supplements such as St John's Wort, traditional medications and herbal remedies. Some of them may affect how this medication works","accessed":"2026-08-27"},{"id":"hh_mir_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/mirtazapine","label":"HealthHub — Mirtazapine: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Mirtazapine as it can worsen the symptoms of your depression and cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"ndf_rem_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12527p/","label":"Singapore National Drug Formulary (HSA/MOH) — REMERON SOLTAB 30 MG [SIN12527P], section 4.2 Posology (adults)","quote":"Treatment should begin with 15 mg daily … The effective daily dose is usually between 15 and 45 mg (the dose should be taken at night) … the dose can be increased up to the maximum dose.","accessed":"2026-08-27"},{"id":"ndf_rem_half","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12527p/","label":"Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], half-life and timing","quote":"Mirtazapine has an elimination half-life of 20–40 hours and therefore Remeron is suitable for once daily administration. It should be taken preferably as a single night-time dose before going to bed.","accessed":"2026-08-27"},{"id":"ndf_rem_onset","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12527p/","label":"Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], onset of effect","quote":"Mirtazapine begins to exert its effect in general after 1–2 weeks of treatment. Treatment with an adequate dose should result in a positive response within 2–4 weeks.","accessed":"2026-08-27"},{"id":"ndf_rem_ped","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12527p/","label":"Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], children and adolescents","quote":"Remeron should not be used in children and adolescents under the age of 18 years … as efficacy was not demonstrated in two short-term clinical trials and because of safety concerns","accessed":"2026-08-27"},{"id":"ndf_rem_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12527p/","label":"Singapore National Drug Formulary — REMERON SOLTAB 30 MG [SIN12527P], section 4.3 Contraindications","quote":"Hypersensitivity to the active substance or to any of the excipients. Concomitant use of mirtazapine with monoamine oxidase (MAO) inhibitors","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:26.600885+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}