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Memantine

Medication NMDA receptor antagonist other
Aka: Ebixa
Brands seen in Singapore: Ebixa, Admenta, Marixino, Nemdatine, Cognimet
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Moderate to severe alzheimer's disease, as prescribed
When to take
HealthHub: once a day, SAMe time daily, food optional
Take with
Water · HealthHub: alcohol can cause excessive sleepiness
Pros & cons
Pros
  • HealthHub: may improve thinking in some patients
  • SG label: one 10 mg strength, one dose a day
  • HealthHub: may be taken with or without food
Cons
  • HealthHub: it does not cure or stop the dementia
  • HealthHub: dizziness, drowsiness, constipation
  • HealthHub: rarely confusion, hallucinations, seizures
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 8 registered memantine products carry Forensicclassification 'Prescription Only' and all are 10 mg film-coated tablets — SIN12315P EBIXA TABLET 10 mg · SIN15609P ADMENTA 10 · SIN15120P MARIXINO · SIN14801P NEMDATINE · SIN16928P COGNIMET”
  2. Singapore National Drug Formulary — EBIXA TABLET 10 MG [SIN12315P], section 4.1 therapeutic indications · read 2026-08-27
    what it says
    “Treatment of patients with moderate to severe Alzheimer's disease.”
  3. Singapore National Drug Formulary — EBIXA TABLET 10 MG [SIN12315P], section 4.2 posology · read 2026-08-27
    what it says
    “The maximum daily dose is 20 mg per day. In order to reduce the risk of undesirable effects the maintenance dose is achieved by upward titration of 5 mg per week over the first 3 weeks”
  4. Singapore National Drug Formulary — EBIXA TABLET 10 MG [SIN12315P], renal and hepatic impairment · read 2026-08-27
    what it says
    “In patients with moderate renal impairment (creatinine clearance 30 - 49 ml/min) daily dose should be 10 mg per day … Administration of Ebixa is not recommended in patients with severe hepatic impairment.”
  5. HealthHub (National Medication Information workgroup, SG) — Memantine: what is this medication for · read 2026-08-27
    what it says
    “It is used to reduce the symptoms of moderate to severe Alzheimer's disease … It will not cure or stop the dementia from getting worse, but it may improve the ability to think in some patients”
  6. HealthHub — Memantine: how should I take this medication · read 2026-08-27
    what it says
    “This medication may be taken with or without food … This medication needs to be taken regularly for a few weeks before you feel its full effects.”
  7. HealthHub — Memantine: common side effects · read 2026-08-27
    what it says
    “Dizziness · Drowsiness or feeling tired · Constipation · Headache · Most of the side effects listed here will improve with time.”
  8. HealthHub — Memantine: rare but serious side effects · read 2026-08-27
    what it says
    “Rarely this medication may cause: Confusion · Seeing or hearing things that are not present (hallucinations) · Mood changes or low mood · Seizures (fits)”
  9. HealthHub — Memantine: what precautions should I take · read 2026-08-27
    what it says
    “You are pregnant, planning to become pregnant, or breastfeeding … Medical conditions such as: Heart, kidney or liver disease · Seizures (fits)”
  10. HealthHub — Memantine: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol while taking Memantine as it can cause excessive sleepiness … Dextromethorphan, a medication used for cough · Amantadine … · Ketamine”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.