{"ok":true,"entry":{"slug":"memantine","kind":"medication","name":"memantine","aliases":["Ebixa"],"brands_sg":["Ebixa","Admenta","Marixino","Nemdatine","Cognimet"],"class":"NMDA receptor antagonist","tags":["other"],"use_for":"moderate to severe alzheimer's disease, as prescribed","use_after":"healthhub: once a day, same time daily, food optional","use_duration":null,"take_with":"water · healthhub: alcohol can cause excessive sleepiness","pros":["healthhub: may improve thinking in some patients","sg label: one 10 mg strength, one dose a day","healthhub: may be taken with or without food"],"cons":["healthhub: it does not cure or stop the dementia","healthhub: dizziness, drowsiness, constipation","healthhub: rarely confusion, hallucinations, seizures"],"dose_note":"the singapore label for ebixa states 'The maximum daily dose is 20 mg per day' and that 'the maintenance dose is achieved by upward titration of 5 mg per week over the first 3 weeks', reaching 'two 10 mg film-coated tablets (20 mg) per day' from week 4; the recommended maintenance dose is 20 mg per day, including for patients over 65. the same label halves that in kidney impairment: 'In patients with moderate renal impairment (creatinine clearance 30 - 49 ml/min) daily dose should be 10 mg per day', and the same 10 mg per day in severe impairment. the prescriber sets and reviews the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["heart, kidney or liver disease (healthhub)","seizures (fits) (healthhub)","pregnancy, planning pregnancy or breastfeeding (healthhub)","severe liver impairment — sg label does not recommend it"],"clashes":[{"src":["hh_mem_avoid"],"food":true,"note":"healthhub: it can cause excessive sleepiness","with":"alcohol"},{"src":["hh_mem_avoid"],"note":"healthhub: may increase the risk of side effects with memantine","with":"dextromethorphan (cough medicine)"},{"src":["hh_mem_avoid"],"note":"healthhub: may increase the risk of side effects with memantine","with":"amantadine"},{"src":["hh_mem_avoid"],"note":"healthhub: may increase the risk of side effects with memantine","with":"ketamine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, cached in full and filtered locally)","quote":"All 8 registered memantine products carry Forensicclassification 'Prescription Only' and all are 10 mg film-coated tablets — SIN12315P EBIXA TABLET 10 mg · SIN15609P ADMENTA 10 · SIN15120P MARIXINO · SIN14801P NEMDATINE · SIN16928P COGNIMET","accessed":"2026-08-27"},{"id":"ndf_ebixa_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12315p/","label":"Singapore National Drug Formulary — EBIXA TABLET 10 MG [SIN12315P], section 4.1 therapeutic indications","quote":"Treatment of patients with moderate to severe Alzheimer's disease.","accessed":"2026-08-27"},{"id":"ndf_ebixa_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12315p/","label":"Singapore National Drug Formulary — EBIXA TABLET 10 MG [SIN12315P], section 4.2 posology","quote":"The maximum daily dose is 20 mg per day. In order to reduce the risk of undesirable effects the maintenance dose is achieved by upward titration of 5 mg per week over the first 3 weeks","accessed":"2026-08-27"},{"id":"ndf_ebixa_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin12315p/","label":"Singapore National Drug Formulary — EBIXA TABLET 10 MG [SIN12315P], renal and hepatic impairment","quote":"In patients with moderate renal impairment (creatinine clearance 30 - 49 ml/min) daily dose should be 10 mg per day … Administration of Ebixa is not recommended in patients with severe hepatic impairment.","accessed":"2026-08-27"},{"id":"hh_mem_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/memantine","label":"HealthHub (National Medication Information workgroup, SG) — Memantine: what is this medication for","quote":"It is used to reduce the symptoms of moderate to severe Alzheimer's disease … It will not cure or stop the dementia from getting worse, but it may improve the ability to think in some patients","accessed":"2026-08-27"},{"id":"hh_mem_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/memantine","label":"HealthHub — Memantine: how should I take this medication","quote":"This medication may be taken with or without food … This medication needs to be taken regularly for a few weeks before you feel its full effects.","accessed":"2026-08-27"},{"id":"hh_mem_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/memantine","label":"HealthHub — Memantine: common side effects","quote":"Dizziness · Drowsiness or feeling tired · Constipation · Headache · Most of the side effects listed here will improve with time.","accessed":"2026-08-27"},{"id":"hh_mem_rare","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/memantine","label":"HealthHub — Memantine: rare but serious side effects","quote":"Rarely this medication may cause: Confusion · Seeing or hearing things that are not present (hallucinations) · Mood changes or low mood · Seizures (fits)","accessed":"2026-08-27"},{"id":"hh_mem_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/memantine","label":"HealthHub — Memantine: what precautions should I take","quote":"You are pregnant, planning to become pregnant, or breastfeeding … Medical conditions such as: Heart, kidney or liver disease · Seizures (fits)","accessed":"2026-08-27"},{"id":"hh_mem_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/memantine","label":"HealthHub — Memantine: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Memantine as it can cause excessive sleepiness … Dextromethorphan, a medication used for cough · Amantadine … · Ketamine","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}