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Mebeverine

Medication antispasmodic digestive
Aka: Duspatalin
Brands seen in Singapore: Duspatalin Retard, Mebetin, Mespazen
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Stomach cramps, spasms and pain, as in IBS
When to take
NHS: about 20 minutes before a meal
Take with
Water · swallowed whole, capsules are not chewed
Pros & cons
Pros
  • NHS: a muscle relaxant that eases gut spasms
  • NHS: does not usually affect driving or machinery
  • SG register: pharmacy-only, no prescription needed
Cons
  • NHS: skin rash, itchy or red skin can occur
  • SG label: not recommended below 18 years of age
  • SG label: symptom relief takes 2 to 4 weeks minimum
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally, not re-fetched) · read 2026-08-27
    what it says
    “All 3 registered mebeverine products carry Forensicclassification 'Pharmacy Only' — SIN07666P DUSPATALIN RETARD CAPSULE 200 mg · SIN09873P MEBETIN TABLET 135 mg · SIN17409P MESPAZEN FILM COATED TABLET 135MG (ATC A03AA04)”
  2. Singapore National Drug Formulary — MESPAZEN FILM COATED TABLET 135MG [SIN17409P], Product Info and Indication · read 2026-08-27
    what it says
    “Forensic Classification PHARMACY ONLY MEDICINES … Mebeverine helps to relax the muscles of the gastro-intestinal tract (gut). This medicine is used to treat symptoms of irritable bowel syndrome (IBS) and similar problems such as chronic irritable colon, spastic constipation”
  3. Singapore National Drug Formulary — MESPAZEN 135 mg [SIN17409P], How much and how often should you take this medicine · read 2026-08-27
    what it says
    “Adults (including the elderly) The recommended dose is one tablet three times a day. Do not take more than three tablets per day … not recommended for use in children and adolescents below 18”
  4. Singapore National Drug Formulary — DUSPATALIN RETARD CAPSULE 200 MG [SIN07666P], Dosage and administration · read 2026-08-27
    what it says
    “Adults Take one capsule twice daily, one in the morning and one in the evening … Symptom relief occurs after a minimum of 2 to 4 weeks of treatment … not recommended for use in children and adolescents below 18”
  5. NHS — Mebeverine: what mebeverine is for · read 2026-08-27
    what it says
    “Mebeverine is a muscle relaxant medicine. It's used to ease spasms in your stomach muscles, which can cause cramping and pain … It can help if you have issues with your digestive system, such as irritable bowel syndrome (IBS).”
  6. NHS — Mebeverine: how to take mebeverine · read 2026-08-27
    what it says
    “swallow tablets or capsules whole with some water … use the spoon that comes with the liquid medicine to help you measure the right dose … try to take it 20 minutes before a meal”
  7. NHS — Mebeverine: side effects of mebeverine · read 2026-08-27
    what it says
    “Side effects of mebeverine include: a skin rash … itchy or red skin – redness can be harder to see on brown or black skin. Mebeverine does not usually affect your ability to drive, ride a bike or use machinery.”
  8. NHS — Mebeverine: who can and cannot take mebeverine · read 2026-08-27
    what it says
    “it may not be suitable if: … you have a condition called paralytic ileus, which affects the muscles in your gut … you have liver or kidney problems … you've been told to avoid foods and medicines containing sucrose”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.