{"ok":true,"entry":{"slug":"mebeverine","kind":"medication","name":"mebeverine","aliases":["Duspatalin"],"brands_sg":["Duspatalin Retard","Mebetin","Mespazen"],"class":"antispasmodic","tags":["digestive"],"use_for":"stomach cramps, spasms and pain, as in ibs","use_after":"nhs: about 20 minutes before a meal","use_duration":null,"take_with":"water · swallowed whole, capsules are not chewed","pros":["nhs: a muscle relaxant that eases gut spasms","nhs: does not usually affect driving or machinery","sg register: pharmacy-only, no prescription needed"],"cons":["nhs: skin rash, itchy or red skin can occur","sg label: not recommended below 18 years of age","sg label: symptom relief takes 2 to 4 weeks minimum"],"dose_note":"the singapore mespazen 135 mg insert on the national drug formulary states “the recommended dose is one tablet three times a day. do not take more than three tablets per day” — three 135 mg tablets is that label's stated ceiling — and adds “try to take the tablet twenty minutes before a meal” and “consult your doctor … if they do not improve after 2 weeks of treatment”. the prolonged-release duspatalin retard 200 mg insert instead reads “take one capsule twice daily, one in the morning and one in the evening”. both sg inserts say the product is “not recommended for use in children and adolescents below 18”. as directed on the label or by your pharmacist.","dosage":null,"ul_status":null,"sg_class":"pharmacy-only","cautions":["paralytic ileus, which affects the muscles in the gut — nhs: may not be suitable","liver or kidney problems — nhs: may not be suitable","under 18 — sg labels: not recommended, insufficient safety and efficacy data","told to avoid sucrose — nhs: may not be suitable"],"clashes":[],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"All 3 registered mebeverine products carry Forensicclassification 'Pharmacy Only' — SIN07666P DUSPATALIN RETARD CAPSULE 200 mg · SIN09873P MEBETIN TABLET 135 mg · SIN17409P MESPAZEN FILM COATED TABLET 135MG (ATC A03AA04)","accessed":"2026-08-27"},{"id":"ndf_mespazen_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin17409p/","label":"Singapore National Drug Formulary — MESPAZEN FILM COATED TABLET 135MG [SIN17409P], Product Info and Indication","quote":"Forensic Classification PHARMACY ONLY MEDICINES … Mebeverine helps to relax the muscles of the gastro-intestinal tract (gut). This medicine is used to treat symptoms of irritable bowel syndrome (IBS) and similar problems such as chronic irritable colon, spastic constipation","accessed":"2026-08-27"},{"id":"ndf_mespazen_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin17409p/","label":"Singapore National Drug Formulary — MESPAZEN 135 mg [SIN17409P], How much and how often should you take this medicine","quote":"Adults (including the elderly) The recommended dose is one tablet three times a day. Do not take more than three tablets per day … not recommended for use in children and adolescents below 18","accessed":"2026-08-27"},{"id":"ndf_duspatalin_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin07666p/","label":"Singapore National Drug Formulary — DUSPATALIN RETARD CAPSULE 200 MG [SIN07666P], Dosage and administration","quote":"Adults Take one capsule twice daily, one in the morning and one in the evening … Symptom relief occurs after a minimum of 2 to 4 weeks of treatment … not recommended for use in children and adolescents below 18","accessed":"2026-08-27"},{"id":"nhs_mebev_about","url":"https://www.nhs.uk/medicines/mebeverine/","label":"NHS — Mebeverine: what mebeverine is for","quote":"Mebeverine is a muscle relaxant medicine. It's used to ease spasms in your stomach muscles, which can cause cramping and pain … It can help if you have issues with your digestive system, such as irritable bowel syndrome (IBS).","accessed":"2026-08-27"},{"id":"nhs_mebev_how","url":"https://www.nhs.uk/medicines/mebeverine/","label":"NHS — Mebeverine: how to take mebeverine","quote":"swallow tablets or capsules whole with some water … use the spoon that comes with the liquid medicine to help you measure the right dose … try to take it 20 minutes before a meal","accessed":"2026-08-27"},{"id":"nhs_mebev_se","url":"https://www.nhs.uk/medicines/mebeverine/","label":"NHS — Mebeverine: side effects of mebeverine","quote":"Side effects of mebeverine include: a skin rash … itchy or red skin – redness can be harder to see on brown or black skin. Mebeverine does not usually affect your ability to drive, ride a bike or use machinery.","accessed":"2026-08-27"},{"id":"nhs_mebev_who","url":"https://www.nhs.uk/medicines/mebeverine/","label":"NHS — Mebeverine: who can and cannot take mebeverine","quote":"it may not be suitable if: … you have a condition called paralytic ileus, which affects the muscles in your gut … you have liver or kidney problems … you've been told to avoid foods and medicines containing sucrose","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}