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Mangosteen

Supplement botanical general nutrition
Aka: Garcinia mangostana, xanthones, alpha-mangostin
Brands seen in Singapore: Swanson Vitamins, Solaray, Advance Physician Formulas, Source Naturals, Dynamic Health
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Marketed as an antioxidant — one small human trial
When to take
No timing data — the human trial used a daily drink
Pros & cons
Pros
  • One 30-day randomised trial in 60 healthy adults
  • That trial saw 15% more blood antioxidant capacity
  • Not listed in HSA's prohibited/restricted annexes
Cons
  • Limited human evidence — mostly animal and lab work
  • Blood-sugar data is in rodents, not people
  • A severe lactic acidosis case is on record
Sources
  1. Xie et al., Food Science & Nutrition 2015 — Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial · read 2026-08-27
    what it says
    “A randomized, double-blind, placebo-controlled clinical trial was conducted using 60 participants … the group given the mangosteen-based drink formula showed 15% more antioxidant capacity in the bloodstream than did the placebo group”
  2. Heliyon 2023 — General toxicity studies of alpha mangostin from Garcinia mangostana: A systematic review · read 2026-08-27
    what it says
    “Toxicity studies were carried out by various methods such as on test animals, interventions, and various routes of administration, but the test results have not been well documented.”
  3. Frontiers in Pharmacology 2024 — Hypoglycemic activity of Garcinia mangostana L. extracts on diabetes rodent models: a systematic review and network meta-analysis · read 2026-08-27
    what it says
    “This study focused on evaluating the hypoglycemic effects of GM on diabetic rodent models.”
  4. Wong & Klemmer, American Journal of Kidney Diseases 2008 — Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana (case report) · read 2026-08-27
    what it says
    “We describe a case of severe lactic acidosis associated with the use of mangosteen juice as a dietary supplement.”
  5. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (118 rows, Abrus to Zinc) and Annex B — both searched, no row for this ingredient · read 2026-08-27
    what it says
    “A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers are responsible to ensure that their products are safe and appropriate for the target consumers.”
  6. iHerb Singapore — Mangosteen category, default (best-selling) order · read 2026-08-27
    what it says
    “1 - 8 of 8 results … Swanson Vitamins, Full Spectrum® Mangosteen, 500 mg … Solaray, Vital Extracts, Mangosteen, 500 mg … Advance Physician Formulas, Mangosteen, 500 mg … Source Naturals, Mangosteen, 60 Tablets … Dynamic Health, Mangosteen Gold”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.