{"ok":true,"entry":{"slug":"mangosteen","kind":"supplement","name":"mangosteen","aliases":["Garcinia mangostana","xanthones","alpha-mangostin"],"brands_sg":["Swanson Vitamins","Solaray","Advance Physician Formulas","Source Naturals","Dynamic Health"],"class":"botanical","tags":["general"],"use_for":"marketed as an antioxidant — one small human trial","use_after":"no timing data — the human trial used a daily drink","use_duration":null,"take_with":null,"pros":["one 30-day randomised trial in 60 healthy adults","that trial saw 15% more blood antioxidant capacity","not listed in HSA's prohibited/restricted annexes"],"cons":["limited human evidence — mostly animal and lab work","blood-sugar data is in rodents, not people","a severe lactic acidosis case is on record"],"dose_note":"the one human trial used a mangosteen-based drink daily for 30 days; no standard supplement dose is established","dosage":{"ul":null,"unit":null,"fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["a case of severe lactic acidosis followed mangosteen juice — ask your doctor first","diabetes medication — the glucose data is rodent-only, not human"],"clashes":[],"sources":[{"id":"mg_rct2015","url":"https://europepmc.org/article/PMC/PMC4534161","label":"Xie et al., Food Science & Nutrition 2015 — Daily consumption of a mangosteen-based drink improves in vivo antioxidant and anti-inflammatory biomarkers in healthy adults: a randomized, double-blind, placebo-controlled clinical trial","quote":"A randomized, double-blind, placebo-controlled clinical trial was conducted using 60 participants … the group given the mangosteen-based drink formula showed 15% more antioxidant capacity in the bloodstream than did the placebo group","accessed":"2026-08-27"},{"id":"mg_tox2023","url":"https://europepmc.org/article/PMC/PMC10196863","label":"Heliyon 2023 — General toxicity studies of alpha mangostin from Garcinia mangostana: A systematic review","quote":"Toxicity studies were carried out by various methods such as on test animals, interventions, and various routes of administration, but the test results have not been well documented.","accessed":"2026-08-27"},{"id":"mg_nma2024","url":"https://europepmc.org/article/PMC/PMC11479905","label":"Frontiers in Pharmacology 2024 — Hypoglycemic activity of Garcinia mangostana L. extracts on diabetes rodent models: a systematic review and network meta-analysis","quote":"This study focused on evaluating the hypoglycemic effects of GM on diabetic rodent models.","accessed":"2026-08-27"},{"id":"mg_acidosis2008","url":"https://europepmc.org/article/MED/18436094","label":"Wong & Klemmer, American Journal of Kidney Diseases 2008 — Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana (case report)","quote":"We describe a case of severe lactic acidosis associated with the use of mangosteen juice as a dietary supplement.","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (118 rows, Abrus to Zinc) and Annex B — both searched, no row for this ingredient","quote":"A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers are responsible to ensure that their products are safe and appropriate for the target consumers.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/mangosteen","label":"iHerb Singapore — Mangosteen category, default (best-selling) order","quote":"1 - 8 of 8 results … Swanson Vitamins, Full Spectrum® Mangosteen, 500 mg … Solaray, Vital Extracts, Mangosteen, 500 mg … Advance Physician Formulas, Mangosteen, 500 mg … Source Naturals, Mangosteen, 60 Tablets … Dynamic Health, Mangosteen Gold","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}