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Manganese

Supplement mineral bone & jointgeneral nutrition
Aka: manganese bisglycinate
Brands seen in Singapore: Solgar, Solaray, Swanson Vitamins, Source Naturals, Bluebonnet Nutrition
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Enzyme cofactor · bone claims allowed by HSA, no solo trials
When to take
Timing not addressed by NIH ODS · no drug clashes listed
Take with
Water · only 1–5% is absorbed; more when iron is low
Pros & cons
Pros
  • Ai is small: 2.3 mg men, 1.8 mg women a day
  • HSA allows bone-health and connective-tissue claims
  • No clinically relevant drug interactions per NIH ODS
Cons
  • Bone benefit: no trials of manganese on its own
  • Excess hits the nervous system — tremor, gait, balance
  • SG pills run 8–50 mg a dose — most above the 11 mg UL
Sources
  1. NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Introduction, Table 1 AIs, absorption · read 2026-08-27
    what it says
    “Manganese is a cofactor for many enzymes … [AI] 19–50 years: Male 2.3 mg, Female 1.8 mg, Pregnancy 2.0 mg, Lactation 2.6 mg … Humans absorb only about 1% to 5% of dietary manganese”
  2. NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Dietary Supplements, iron and absorption · read 2026-08-27
    what it says
    “manganese is present in many different forms, including amino acid chelates (e.g., manganese bisglycinate chelate …) … Dietary iron intakes and iron status … appear to be inversely associated with manganese absorption”
  3. NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Table 3 ULs, Health Risks from Excessive Manganese · read 2026-08-27
    what it says
    “[UL] 19+ years: 11 mg … Manganese toxicity mainly affects the central nervous system and can cause tremors, muscle spasms, tinnitus, hearing loss, and the feeling of being unsteady … changes in gait and balance, tremor, and rigidity”
  4. NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Health Risks: iron deficiency, chronic liver disease · read 2026-08-27
    what it says
    “Iron deficiency increases manganese absorption and can therefore exacerbate symptoms of manganese toxicity … People with chronic liver disease have impaired manganese elimination in bile and are more susceptible to manganese neurotoxicity”
  5. NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — dietary toxicity, Interactions with Medications, Manganese Deficiency · read 2026-08-27
    what it says
    “No evidence shows manganese toxicity from high dietary manganese intakes … Manganese is not known to have any clinically relevant interactions with medications … Manganese deficiency is very rare in humans”
  6. NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Manganese and Health: Bone health · read 2026-08-27
    what it says
    “More research is needed to determine whether manganese supplementation affects bone health in humans … No clinical trials have evaluated the effects of manganese supplementation alone on bone health”
  7. FDA — Daily Value on the Nutrition and Supplement Facts Labels, Reference Guide: Daily Values for Nutrients (content current as of 03/05/2024) · read 2026-08-27
    what it says
    “DVs are the recommended amounts of nutrients to consume or not to exceed each day … Manganese 2.3mg”
  8. HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), clause 4.8 + Table 5 Minerals Limits · read 2026-08-27
    what it says
    “4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5 … Table 5: Minerals Limits … Manganese 3.5 mg”
  9. HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), List of Health Claims rows 25, 96, 99 · read 2026-08-27
    what it says
    “Contribute to normal functioning of connective tissue • Manganese … Aid/assist healthy bone development/growth/building • Magnesium, manganese … Maintain/support bone health • Boron, calcium, magnesium, manganese, phosphorus, zinc”
  10. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. 001 (October 2025), Annex A row 66 · read 2026-08-27
    what it says
    “66. Manganese — Restricted use in HS and TM — Maximum Daily Dose: When for oral use by general adult population, the maximum recommended daily dose should not provide more than 3.5mg”
  11. iHerb Singapore — Manganese category page (Minerals), default 'Featured' order, 14 results · read 2026-08-27
    what it says
    “Solgar, Chelated Manganese … (8 mg per Tablet) … Solaray, Manganese, Advanced Chelate Complex, 50 mg … Swanson Vitamins, Albion® Manganese, 10 mg … Source Naturals, Manganese, 10 mg … Bluebonnet Nutrition, Chelated Manganese, 10 mg”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.