{"ok":true,"entry":{"slug":"manganese","kind":"supplement","name":"manganese","aliases":["manganese bisglycinate"],"brands_sg":["Solgar","Solaray","Swanson Vitamins","Source Naturals","Bluebonnet Nutrition"],"class":"mineral","tags":["bone-joint","general"],"use_for":"enzyme cofactor · bone claims allowed by hsa, no solo trials","use_after":"timing not addressed by nih ods · no drug clashes listed","use_duration":null,"take_with":"water · only 1–5% is absorbed; more when iron is low","pros":["ai is small: 2.3 mg men, 1.8 mg women a day","hsa allows bone-health and connective-tissue claims","no clinically relevant drug interactions per nih ods"],"cons":["bone benefit: no trials of manganese on its own","excess hits the nervous system — tremor, gait, balance","sg pills run 8–50 mg a dose — most above the 11 mg ul"],"dose_note":"ai 2.3 mg (men) / 1.8 mg (women) a day — no rda exists; ul 11 mg a day for adults; hsa caps general-adult health supplements in singapore at 3.5 mg a day; sg iherb listings run 8 mg (solgar) to 50 mg (solaray) a dose — all above the hsa cap and most above the ul; nih ods: deficiency is very rare and no toxicity has been shown from high dietary intakes","dosage":{"ul":"11 mg","unit":"mg","fda_dv":"2.3 mg","rda_ai":"AI 2.3 mg men · 1.8 mg women (19+) · 2.0 mg pregnancy · 2.6 mg lactation","ul_status":"established","population":"general adult","hsa_max_daily":"3.5 mg"},"ul_status":"established","sg_class":null,"cautions":["chronic liver disease — manganese clears poorly in bile; more prone to nerve effects; ask your doctor first","iron deficiency — more manganese is absorbed, so excess hits harder; ask your doctor","over 11 mg a day — above the ul; only under a doctor's care"],"clashes":[{"src":["nih_ods_mn_forms"],"note":"iron intake and iron status track inversely with manganese absorption — a nutrient interaction, not a drug one","with":"iron (supplements or high intake)"}],"sources":[{"id":"nih_ods_mn_intake","url":"https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/","label":"NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Introduction, Table 1 AIs, absorption","quote":"Manganese is a cofactor for many enzymes … [AI] 19–50 years: Male 2.3 mg, Female 1.8 mg, Pregnancy 2.0 mg, Lactation 2.6 mg … Humans absorb only about 1% to 5% of dietary manganese","accessed":"2026-08-27"},{"id":"nih_ods_mn_forms","url":"https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/","label":"NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Dietary Supplements, iron and absorption","quote":"manganese is present in many different forms, including amino acid chelates (e.g., manganese bisglycinate chelate …) … Dietary iron intakes and iron status … appear to be inversely associated with manganese absorption","accessed":"2026-08-27"},{"id":"nih_ods_mn_safety","url":"https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/","label":"NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Table 3 ULs, Health Risks from Excessive Manganese","quote":"[UL] 19+ years: 11 mg … Manganese toxicity mainly affects the central nervous system and can cause tremors, muscle spasms, tinnitus, hearing loss, and the feeling of being unsteady … changes in gait and balance, tremor, and rigidity","accessed":"2026-08-27"},{"id":"nih_ods_mn_groups","url":"https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/","label":"NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Health Risks: iron deficiency, chronic liver disease","quote":"Iron deficiency increases manganese absorption and can therefore exacerbate symptoms of manganese toxicity … People with chronic liver disease have impaired manganese elimination in bile and are more susceptible to manganese neurotoxicity","accessed":"2026-08-27"},{"id":"nih_ods_mn_health","url":"https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/","label":"NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — dietary toxicity, Interactions with Medications, Manganese Deficiency","quote":"No evidence shows manganese toxicity from high dietary manganese intakes … Manganese is not known to have any clinically relevant interactions with medications … Manganese deficiency is very rare in humans","accessed":"2026-08-27"},{"id":"nih_ods_mn_bone","url":"https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/","label":"NIH ODS — Manganese Fact Sheet for Health Professionals (Updated: March 29, 2021) — Manganese and Health: Bone health","quote":"More research is needed to determine whether manganese supplementation affects bone health in humans … No clinical trials have evaluated the effects of manganese supplementation alone on bone health","accessed":"2026-08-27"},{"id":"fda_dv","url":"https://www.fda.gov/food/nutrition-facts-label/daily-value-nutrition-and-supplement-facts-labels","label":"FDA — Daily Value on the Nutrition and Supplement Facts Labels, Reference Guide: Daily Values for Nutrients (content current as of 03/05/2024)","quote":"DVs are the recommended amounts of nutrients to consume or not to exceed each day … Manganese 2.3mg","accessed":"2026-08-27"},{"id":"hsa_hs_limits","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), clause 4.8 + Table 5 Minerals Limits","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5 … Table 5: Minerals Limits … Manganese 3.5 mg","accessed":"2026-08-27"},{"id":"hsa_hs_claims","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines GL-CHPB-3-001 Rev. 020 (January 2026), List of Health Claims rows 25, 96, 99","quote":"Contribute to normal functioning of connective tissue • Manganese … Aid/assist healthy bone development/growth/building • Magnesium, manganese … Maintain/support bone health • Boron, calcium, magnesium, manganese, phosphorus, zinc","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. 001 (October 2025), Annex A row 66","quote":"66. Manganese — Restricted use in HS and TM — Maximum Daily Dose: When for oral use by general adult population, the maximum recommended daily dose should not provide more than 3.5mg","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/manganese","label":"iHerb Singapore — Manganese category page (Minerals), default 'Featured' order, 14 results","quote":"Solgar, Chelated Manganese … (8 mg per Tablet) … Solaray, Manganese, Advanced Chelate Complex, 50 mg … Swanson Vitamins, Albion® Manganese, 10 mg … Source Naturals, Manganese, 10 mg … Bluebonnet Nutrition, Chelated Manganese, 10 mg","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}