Maitake
Supplement
mushroom
immune
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Immune and cognitive markers — results differ by strain
When to take
Daily
Take with
The 18-week trial baked 50 g of whole maitake into bread
Studied for
The two 2026 trials ran 11 to 18 weeks
Pros & cons
Pros
- Two 2026 RCTS in healthy adults, not patients
- Moca-j score rose vs placebo for the y10m strain
- Nk cell activity rose in the SAMe y10m group
Cons
- Only one of two strains moved the score
- Urti episode counts did not differ from placebo
- 47 people, 18 weeks — small and short
Sources
- Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial (J Nutr Sci Vitaminol 2026) — design · read 2026-08-27
what it says
“We conducted a randomized, double-blind, placebo-controlled trial over 18 wk targeting 47 healthy Japanese individuals aged 60 y or older … a Y10M group consumed bread containing 50 g of the maitake mushroom strain Y10M”
- Maitake cognitive RCT, J Nutr Sci Vitaminol 2026 — cognitive result · read 2026-08-27
what it says
“The Y10M group showed a significant improvement in cognitive assessment based on the Japanese version of the Montreal Cognitive Assessment (MoCA-J) score compared to the placebo group … no difference was observed … between the C5304 and placebo groups”
- Maitake cognitive RCT, J Nutr Sci Vitaminol 2026 — immune result · read 2026-08-27
what it says
“The activity of natural killer cells, a type of immune cell, was also significantly augmented in the Y10M group and positively correlated with MoCA-J scores.”
- Maitake cognitive RCT, J Nutr Sci Vitaminol 2026 — tolerability · read 2026-08-27
what it says
“No participants discontinued the intervention due to adverse effects in any group.”
- Maitake mushroom supplementation modulates upper respiratory symptoms and immune responses in healthy adults: a randomized, double-blind, placebo-controlled trial (Food Funct 2026) — design · read 2026-08-27
what it says
“healthy young adults (18-20 years) and middle-aged/older adults (40-85 years) consumed bread containing one of two maitake strains (Y10M or C5304) or a placebo daily for 11 weeks (young adults) or 18 weeks”
- Maitake upper-respiratory RCT, Food Funct 2026 — results · read 2026-08-27
what it says
“While the overall incidence of URTI episodes did not differ between groups, symptom-specific analyses suggested strain-dependent differences. Y10M supplementation was associated with fewer cumulative days of fever and runny nose in both age groups”
- HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A/B — searched, no row for this ingredient · read 2026-08-27
what it says
“The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
- iHerb Singapore — Maitake category (default order, 17 results); first 5 distinct brands: California Gold Nutrition, Mushroom Wisdom, Host Defense, Solaray, Super Nutrition · read 2026-08-27
what it says
“California Gold Nutrition, Ergothioneine Mushroom Complex with Organic Maitake … Mushroom Wisdom, Maitake D Fraction®, Pro 4X … Host Defense, Mushrooms™, Maitake … Solaray, Organic Fermented Maitake … Super Nutrition, Organic Maitake Mushroom + Ginger”
Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.