{"ok":true,"entry":{"slug":"maitake","kind":"supplement","name":"maitake","aliases":["Grifola frondosa","hen of the woods"],"brands_sg":["California Gold Nutrition","Mushroom Wisdom","Host Defense","Solaray","Super Nutrition"],"class":"mushroom","tags":["immune"],"use_for":"immune and cognitive markers — results differ by strain","use_after":"daily","use_duration":"the two 2026 trials ran 11 to 18 weeks","take_with":"the 18-week trial baked 50 g of whole maitake into bread","pros":["two 2026 rcts in healthy adults, not patients","moca-j score rose vs placebo for the y10m strain","nk cell activity rose in the same y10m group"],"cons":["only one of two strains moved the score","urti episode counts did not differ from placebo","47 people, 18 weeks — small and short"],"dose_note":"the 2026 cognitive trial gave bread containing 50 g of whole maitake (strain y10m or c5304) daily for 18 weeks to 47 healthy japanese adults aged 60 or over; the respiratory-symptom trial used the same bread daily for 11 weeks in 18-20 year olds and 18 weeks in 40-85 year olds; no dose is established and both trials found the result depended on the strain","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["both trials tested whole maitake baked into bread — capsules, powders and extracts are a different product","the benefit split by strain: y10m moved the outcomes, c5304 showed limited effects","overall urti incidence did not differ from placebo, so the immune tag rests on markers and symptom-days, not on fewer infections","not listed in hsa's annex a/b — hsa says that list is not exhaustive"],"clashes":[],"sources":[{"id":"maitake_cog2026_design","url":"https://europepmc.org/article/MED/42055721","label":"Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial (J Nutr Sci Vitaminol 2026) — design","quote":"We conducted a randomized, double-blind, placebo-controlled trial over 18 wk targeting 47 healthy Japanese individuals aged 60 y or older … a Y10M group consumed bread containing 50 g of the maitake mushroom strain Y10M","accessed":"2026-08-27"},{"id":"maitake_cog2026_result","url":"https://europepmc.org/article/MED/42055721","label":"Maitake cognitive RCT, J Nutr Sci Vitaminol 2026 — cognitive result","quote":"The Y10M group showed a significant improvement in cognitive assessment based on the Japanese version of the Montreal Cognitive Assessment (MoCA-J) score compared to the placebo group … no difference was observed … between the C5304 and placebo groups","accessed":"2026-08-27"},{"id":"maitake_cog2026_nk","url":"https://europepmc.org/article/MED/42055721","label":"Maitake cognitive RCT, J Nutr Sci Vitaminol 2026 — immune result","quote":"The activity of natural killer cells, a type of immune cell, was also significantly augmented in the Y10M group and positively correlated with MoCA-J scores.","accessed":"2026-08-27"},{"id":"maitake_cog2026_safety","url":"https://europepmc.org/article/MED/42055721","label":"Maitake cognitive RCT, J Nutr Sci Vitaminol 2026 — tolerability","quote":"No participants discontinued the intervention due to adverse effects in any group.","accessed":"2026-08-27"},{"id":"maitake_urti2026_design","url":"https://europepmc.org/article/MED/42627298","label":"Maitake mushroom supplementation modulates upper respiratory symptoms and immune responses in healthy adults: a randomized, double-blind, placebo-controlled trial (Food Funct 2026) — design","quote":"healthy young adults (18-20 years) and middle-aged/older adults (40-85 years) consumed bread containing one of two maitake strains (Y10M or C5304) or a placebo daily for 11 weeks (young adults) or 18 weeks","accessed":"2026-08-27"},{"id":"maitake_urti2026_result","url":"https://europepmc.org/article/MED/42627298","label":"Maitake upper-respiratory RCT, Food Funct 2026 — results","quote":"While the overall incidence of URTI episodes did not differ between groups, symptom-specific analyses suggested strain-dependent differences. Y10M supplementation was associated with fewer cumulative days of fever and runny nose in both age groups","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A/B — searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/maitake","label":"iHerb Singapore — Maitake category (default order, 17 results); first 5 distinct brands: California Gold Nutrition, Mushroom Wisdom, Host Defense, Solaray, Super Nutrition","quote":"California Gold Nutrition, Ergothioneine Mushroom Complex with Organic Maitake … Mushroom Wisdom, Maitake D Fraction®, Pro 4X … Host Defense, Mushrooms™, Maitake … Solaray, Organic Fermented Maitake … Super Nutrition, Organic Maitake Mushroom + Ginger","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}