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Luteolin

Supplement flavonoid brain & moodimmune
Aka: luteolin complex
Brands seen in Singapore: California Gold Nutrition, Nutricost, Life Extension, Swanson Vitamins, Double Wood Supplements
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — studied with PEA for smell loss
Pros & cons
Pros
  • 7 RCTs (525 people) tested PEA-luteolin with training
  • Not named in HSA's prohibited or restricted annexes
Cons
  • Trials used a PEA-luteolin combo, not luteolin alone
  • Cognitive and immune claims rest on preclinical work
  • No RDA, no upper limit, no SG cap set
Sources
  1. Therapeutic effect of anti-neuroinflammatory supplement combined with olfactory training on post-covid olfactory dysfunction: systematic review and meta-analysis (Eur Arch Otorhinolaryngol 2026) · read 2026-08-27
    what it says
    “7 eligible RCTs published between 2021 and 2024 were included, comprising 525 patients … patients receiving PEA-LUT combined with OT had significantly higher TDI scores (SMD = 0.90; 95% CI: 0.24-1.58; P < 0.01)”
  2. Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline (2026) — PREPRINT, not peer-reviewed · read 2026-08-27
    what it says
    “This narrative review examines the biological rationale and available evidence regarding palmitoylethanolamide (PEA), luteolin, and their co-ultramicronized formulation (PEA-Lut) … Preclinical studies suggest that PEA-Lut may attenuate glial activation”
  3. HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B · read 2026-08-27
    what it says
    “Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [luteolin appears in neither annex]”
  4. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names luteolin]”
  5. iHerb Singapore — Luteolin category page, default listing order (1 - 7 of 7 results) · read 2026-08-27
    what it says
    “California Gold Nutrition, NMN Complex … Apigenin, and Luteolin … Nutricost, Luteolin, 100 mg, 120 Capsules … Life Extension, Geroprotect®, Autophagy Renew … Swanson Vitamins, Luteolin Complex, 30 Veggie Caps … Double Wood Supplements, Luteolin, 120 Capsules”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.