{"ok":true,"entry":{"slug":"luteolin","kind":"supplement","name":"luteolin","aliases":["luteolin complex"],"brands_sg":["California Gold Nutrition","Nutricost","Life Extension","Swanson Vitamins","Double Wood Supplements"],"class":"flavonoid","tags":["cognitive","immune"],"use_for":"limited human evidence — studied with PEA for smell loss","use_after":null,"use_duration":null,"take_with":null,"pros":["7 RCTs (525 people) tested PEA-luteolin with training","not named in HSA's prohibited or restricted annexes"],"cons":["trials used a PEA-luteolin combo, not luteolin alone","cognitive and immune claims rest on preclinical work","no RDA, no upper limit, no SG cap set"],"dose_note":"the pooled trials used a co-ultramicronized palmitoylethanolamide–luteolin product alongside olfactory training; no luteolin-only dose is established","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the evidence base is a combination product, not luteolin alone","no upper limit set — absence of a cap is not safety"],"clashes":[],"sources":[{"id":"pealut_olf","url":"https://europepmc.org/article/MED/41559316","label":"Therapeutic effect of anti-neuroinflammatory supplement combined with olfactory training on post-covid olfactory dysfunction: systematic review and meta-analysis (Eur Arch Otorhinolaryngol 2026)","quote":"7 eligible RCTs published between 2021 and 2024 were included, comprising 525 patients … patients receiving PEA-LUT combined with OT had significantly higher TDI scores (SMD = 0.90; 95% CI: 0.24-1.58; P < 0.01)","accessed":"2026-08-27"},{"id":"pealut_brain","url":"https://europepmc.org/article/PPR/PPR1291306","label":"Palmitoylethanolamide and Luteolin in Brain Aging and Cognitive Decline (2026) — PREPRINT, not peer-reviewed","quote":"This narrative review examines the biological rationale and available evidence regarding palmitoylethanolamide (PEA), luteolin, and their co-ultramicronized formulation (PEA-Lut) … Preclinical studies suggest that PEA-Lut may attenuate glial activation","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B","quote":"Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [luteolin appears in neither annex]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names luteolin]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/luteolin","label":"iHerb Singapore — Luteolin category page, default listing order (1 - 7 of 7 results)","quote":"California Gold Nutrition, NMN Complex … Apigenin, and Luteolin … Nutricost, Luteolin, 100 mg, 120 Capsules … Life Extension, Geroprotect®, Autophagy Renew … Swanson Vitamins, Luteolin Complex, 30 Veggie Caps … Double Wood Supplements, Luteolin, 120 Capsules","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}