← All medications

Linagliptin

Medication DPP-4 inhibitor diabetes
Aka: Trajenta
Brands seen in Singapore: Trajenta, Trajenta Duo, Glyxambi
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for type 2 diabetes, with diet and exercise
When to take
NHS: once a day, best at the SAMe time each day
Take with
Water · NHS: with or without food, swallowed whole
Pros & cons
Pros
  • FDA label: 5 mg once daily, no titration step
  • NHS: with or without food
  • HealthHub: raises insulin release after a meal
Cons
  • NHS: blocked nose, cough, constipation
  • FDA: acute pancreatitis, including fatal cases
  • FDA: severe joint pain and bullous pemphigoid reported
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally) · read 2026-08-27
    what it says
    “All 6 registered linagliptin products carry Forensicclassification 'Prescription Only' — SIN14101P Trajenta Film-Coated Tablets 5mg · SIN14377/14378/14379P TRAJENTA DUO 2.5MG with metformin · SIN15272/15273P GLYXAMBI 5 MG with empagliflozin”
  2. NHS Medicines A-Z — Linagliptin: what linagliptin is for · read 2026-08-27
    what it says
    “Linagliptin is a medicine used to treat type 2 diabetes. It's only available with a prescription. … Linagliptin works by increasing the amount of insulin your body produces and lowering your blood sugar level.”
  3. NHS Medicines A-Z — Linagliptin: how to take linagliptin · read 2026-08-27
    what it says
    “Linagliptin comes as tablets you take once a day … swallow the tablets whole with a glass of water (do not crush or chew them) … you can take it with or without food”
  4. NHS Medicines A-Z — Linagliptin: side effects · read 2026-08-27
    what it says
    “Side effects of linagliptin include: cold-like symptoms, such as a blocked nose; a cough; constipation … If you take linagliptin alongside another diabetic medicine, it may cause low blood sugar (hypoglycaemia, or a hypo).”
  5. NHS Medicines A-Z — Linagliptin: who can and cannot take it, pregnancy and breastfeeding · read 2026-08-27
    what it says
    “it may not be not suitable for you if: you've had an allergic reaction … you've had pancreatitis … Linagliptin is usually not used if you're breastfeeding … Linagliptin is not used during pregnancy.”
  6. NHS Medicines A-Z — Linagliptin: taking it with other medicines · read 2026-08-27
    what it says
    “medicines to treat epilepsy or nerve pain, such as carbamazepine; rifampicin, a type of antibiotic; other medicines for high blood sugar, such as insulin, metformin or gliclazide — your doctor may want to change your dose”
  7. NHS Medicines A-Z — Linagliptin: food and alcohol · read 2026-08-27
    what it says
    “It's best not to drink alcohol while taking linagliptin because it can affect your blood sugar level.”
  8. HealthHub (Pharmaceutical Society of Singapore) — Linagliptin: what is this medication for · read 2026-08-27
    what it says
    “Linagliptin is used in the treatment of diabetes by helping to increase the insulin release after a meal and decrease the amount of sugar made by the liver.”
  9. HealthHub — Linagliptin: what precautions should I take · read 2026-08-27
    what it says
    “Have pancreas problem such as pancreatitis … Have gallstones, drink alcohol very often or have very high levels of triglycerides … These medical conditions can increase your chances of getting pancreatitis.”
  10. HealthHub — Linagliptin: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid taking alcohol with this medication as this can increase your chance of developing pancreatitis.”
  11. US FDA label for TRADJENTA (linagliptin) tablets, section 2 Dosage and Administration, via openFDA drug/label.json (effective 2024-01-22) · read 2026-08-27
    what it says
    “The recommended dosage of TRADJENTA is 5 mg taken orally once daily, with or without food.”
  12. US FDA label for TRADJENTA, section 1 Indications and Usage, via openFDA · read 2026-08-27
    what it says
    “TRADJENTA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus … Not recommended in patients with type 1 diabetes mellitus as it would not be effective”
  13. US FDA label for TRADJENTA, section 5 Warnings and Precautions, via openFDA · read 2026-08-27
    what it says
    “Pancreatitis: There have been reports of acute pancreatitis, including fatal pancreatitis … Arthralgia: Severe and disabling arthralgia has been reported … Bullous pemphigoid … Heart failure has been observed with two other members of the DPP-4 inhibitor class.”
  14. US FDA label for TRADJENTA, section 7 Drug Interactions, via openFDA · read 2026-08-27
    what it says
    “The efficacy of TRADJENTA may be reduced when administered in combination (e.g., with rifampin). Use of alternative treatments is strongly recommended … The risk of hypoglycemia is increased when linagliptin is used with an insulin secretagogue or insulin.”
Report a correction View as JSON

Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.