{"ok":true,"entry":{"slug":"linagliptin","kind":"medication","name":"linagliptin","aliases":["Trajenta"],"brands_sg":["Trajenta","Trajenta Duo","Glyxambi"],"class":"DPP-4 inhibitor","tags":["diabetes"],"use_for":"prescribed for type 2 diabetes, with diet and exercise","use_after":"nhs: once a day, best at the same time each day","use_duration":null,"take_with":"water · nhs: with or without food, swallowed whole","pros":["fda label: 5 mg once daily, no titration step","nhs: with or without food","healthhub: raises insulin release after a meal"],"cons":["nhs: blocked nose, cough, constipation","fda: acute pancreatitis, including fatal cases","fda: severe joint pain and bullous pemphigoid reported"],"dose_note":"the us fda label for tradjenta states 'The recommended dosage of TRADJENTA is 5 mg taken orally once daily, with or without food' — 5 mg once daily is the whole adult label range, with no higher step. on the sg register trajenta is a 5 mg tablet, and the trajenta duo and glyxambi fixed-dose combinations each contain 2.5 mg or 5 mg of linagliptin. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pancreatitis, gallstones, frequent alcohol or high triglycerides (healthhub)","pregnancy or breastfeeding — nhs: not used","known risk factors for heart failure — fda: weigh risks and benefits","type 1 diabetes — fda: not recommended, it would not be effective"],"clashes":[{"src":["fda_lina_di","nhs_lina_mix"],"note":"fda: efficacy may be reduced; alternative treatments are strongly recommended","with":"rifampicin and other strong p-gp or cyp3a4 inducers"},{"src":["fda_lina_di","nhs_lina_mix"],"note":"fda: risk of hypoglycaemia is increased; lower doses of those medicines may be needed","with":"insulin or sulfonylureas such as gliclazide"},{"src":["nhs_lina_mix"],"note":"nhs lists epilepsy and nerve-pain medicines such as carbamazepine among those that may not mix well","with":"carbamazepine"},{"src":["hh_lina_food","nhs_lina_food"],"food":true,"note":"healthhub: can increase the chance of pancreatitis; nhs: it can affect blood sugar levels","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally)","quote":"All 6 registered linagliptin products carry Forensicclassification 'Prescription Only' — SIN14101P Trajenta Film-Coated Tablets 5mg · SIN14377/14378/14379P TRAJENTA DUO 2.5MG with metformin · SIN15272/15273P GLYXAMBI 5 MG with empagliflozin","accessed":"2026-08-27"},{"id":"nhs_lina_about","url":"https://www.nhs.uk/medicines/linagliptin/","label":"NHS Medicines A-Z — Linagliptin: what linagliptin is for","quote":"Linagliptin is a medicine used to treat type 2 diabetes. It's only available with a prescription. … Linagliptin works by increasing the amount of insulin your body produces and lowering your blood sugar level.","accessed":"2026-08-27"},{"id":"nhs_lina_howto","url":"https://www.nhs.uk/medicines/linagliptin/","label":"NHS Medicines A-Z — Linagliptin: how to take linagliptin","quote":"Linagliptin comes as tablets you take once a day … swallow the tablets whole with a glass of water (do not crush or chew them) … you can take it with or without food","accessed":"2026-08-27"},{"id":"nhs_lina_side","url":"https://www.nhs.uk/medicines/linagliptin/","label":"NHS Medicines A-Z — Linagliptin: side effects","quote":"Side effects of linagliptin include: cold-like symptoms, such as a blocked nose; a cough; constipation … If you take linagliptin alongside another diabetic medicine, it may cause low blood sugar (hypoglycaemia, or a hypo).","accessed":"2026-08-27"},{"id":"nhs_lina_who","url":"https://www.nhs.uk/medicines/linagliptin/","label":"NHS Medicines A-Z — Linagliptin: who can and cannot take it, pregnancy and breastfeeding","quote":"it may not be not suitable for you if: you've had an allergic reaction … you've had pancreatitis … Linagliptin is usually not used if you're breastfeeding … Linagliptin is not used during pregnancy.","accessed":"2026-08-27"},{"id":"nhs_lina_mix","url":"https://www.nhs.uk/medicines/linagliptin/","label":"NHS Medicines A-Z — Linagliptin: taking it with other medicines","quote":"medicines to treat epilepsy or nerve pain, such as carbamazepine; rifampicin, a type of antibiotic; other medicines for high blood sugar, such as insulin, metformin or gliclazide — your doctor may want to change your dose","accessed":"2026-08-27"},{"id":"nhs_lina_food","url":"https://www.nhs.uk/medicines/linagliptin/","label":"NHS Medicines A-Z — Linagliptin: food and alcohol","quote":"It's best not to drink alcohol while taking linagliptin because it can affect your blood sugar level.","accessed":"2026-08-27"},{"id":"hh_lina_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/linagliptin","label":"HealthHub (Pharmaceutical Society of Singapore) — Linagliptin: what is this medication for","quote":"Linagliptin is used in the treatment of diabetes by helping to increase the insulin release after a meal and decrease the amount of sugar made by the liver.","accessed":"2026-08-27"},{"id":"hh_lina_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/linagliptin","label":"HealthHub — Linagliptin: what precautions should I take","quote":"Have pancreas problem such as pancreatitis … Have gallstones, drink alcohol very often or have very high levels of triglycerides … These medical conditions can increase your chances of getting pancreatitis.","accessed":"2026-08-27"},{"id":"hh_lina_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/linagliptin","label":"HealthHub — Linagliptin: what food or medication should I avoid","quote":"Avoid taking alcohol with this medication as this can increase your chance of developing pancreatitis.","accessed":"2026-08-27"},{"id":"fda_lina_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRADJENTA%22&limit=1","label":"US FDA label for TRADJENTA (linagliptin) tablets, section 2 Dosage and Administration, via openFDA drug/label.json (effective 2024-01-22)","quote":"The recommended dosage of TRADJENTA is 5 mg taken orally once daily, with or without food.","accessed":"2026-08-27"},{"id":"fda_lina_about","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRADJENTA%22&limit=1","label":"US FDA label for TRADJENTA, section 1 Indications and Usage, via openFDA","quote":"TRADJENTA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus … Not recommended in patients with type 1 diabetes mellitus as it would not be effective","accessed":"2026-08-27"},{"id":"fda_lina_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRADJENTA%22&limit=1","label":"US FDA label for TRADJENTA, section 5 Warnings and Precautions, via openFDA","quote":"Pancreatitis: There have been reports of acute pancreatitis, including fatal pancreatitis … Arthralgia: Severe and disabling arthralgia has been reported … Bullous pemphigoid … Heart failure has been observed with two other members of the DPP-4 inhibitor class.","accessed":"2026-08-27"},{"id":"fda_lina_di","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRADJENTA%22&limit=1","label":"US FDA label for TRADJENTA, section 7 Drug Interactions, via openFDA","quote":"The efficacy of TRADJENTA may be reduced when administered in combination (e.g., with rifampin). Use of alternative treatments is strongly recommended … The risk of hypoglycemia is increased when linagliptin is used with an insulin secretagogue or insulin.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:24.715168+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}