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Levofloxacin

Medication fluoroquinolone antibiotic antibiotic
Aka: Cravit
Brands seen in Singapore: Cravit, Locikline, Lufi, Avatac, Levores
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for bacterial infections — your doctor decides
When to take
Once daily, at the SAMe time each day (SG leaflet)
Take with
Water · with or without food; 2 h apart from antacids
Pros & cons
Pros
  • SG leaflet: with or without food
  • Usually once a day for the listed infections
  • Tablets, infusion and eye drops all registered in SG
Cons
  • Boxed warning: tendon, nerve and CNS reactions
  • Can worsen myasthenia gravis — labels warn
  • Sun sensitivity, nausea and diarrhoea are common
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset; filtered locally for levofloxacin) · read 2026-08-27
    what it says
    “Forensicclassification = 'Prescription Only' for all 19 levofloxacin rows (11 oral tablets, 6 infusions, 2 eye drops) — e.g. SIN11632P CRAVIT TABLET 500 mg; SIN13953P LOCIKLINE TABLETS 500MG; SIN11826P CRAVIT OPHTHALMIC SOLUTION 0.5% w/v”
  2. MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], product information · read 2026-08-27
    what it says
    “LEVOFLOXACIN - 500 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA”
  3. MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], indications and usage · read 2026-08-27
    what it says
    “CRAVIT ® Tablets are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms”
  4. MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], dosage and administration · read 2026-08-27
    what it says
    “The usual dose of CRAVIT ® Tablets is 250 mg or 500 mg administered orally, as indicated by infection … Oral doses should be administered at least two hours before or two hours after antacids containing magnesium, aluminum”
  5. MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], contraindications · read 2026-08-27
    what it says
    “Levofloxacin is contraindicated in persons with a history of hypersensitivity to levofloxacin, quinolone antimicrobial agents, or any other components of this product.”
  6. HealthHub (National Medication Information workgroup / Pharmaceutical Society of Singapore) — Levofloxacin, reviewed 31 May 2024 · read 2026-08-27
    what it says
    “Levofloxacin is an antibiotic that is used to treat bacterial infections. These infections may include those of the lungs, bone, joints, skin, eyes and ears.”
  7. HealthHub — Levofloxacin: how should I take or use this medication · read 2026-08-27
    what it says
    “You may take this medication with or without food. Take this medication at the same time each day. Complete the course of antibiotics as prescribed by your doctor.”
  8. HealthHub — Levofloxacin: what precautions should I take · read 2026-08-27
    what it says
    “Inform your healthcare professional if: You have any other medical conditions such as: Epilepsy (fits or seizures) Myasthenia gravis … You have existing heart problems or are on any medicine that regulates your heartbeat … G6PD deficiency”
  9. HealthHub — Levofloxacin: common and serious side effects · read 2026-08-27
    what it says
    “Nausea, vomiting or loss of appetite … Diarrhoea … Dizziness … Increased sensitivity to sunlight … Painful swelling of the joints or tendons … Seizures (fits)”
  10. HealthHub — Levofloxacin: what food or medication should I avoid · read 2026-08-27
    what it says
    “Milk-containing products … Indigestion remedies (e.g. Antacids) … supplements that contain aluminium, calcium, iron, magnesium or zinc … 2 hours before or after Levofloxacin … NSAIDs Theophylline Cyclosporine Probenecid”
  11. FDA DailyMed — Levofloxacin tablets (NuCare Pharmaceuticals), Dosage & Administration, eff. 2025-03-04 · read 2026-08-27
    what it says
    “Type of Infection Dose Every 24 hours Duration (days) Nosocomial Pneumonia 750 mg 7 to 14 … Complicated SSSI 750 mg 7 to 14 … Uncomplicated UTI 250 mg 3”
  12. FDA DailyMed — Levofloxacin tablets, Boxed Warning · read 2026-08-27
    what it says
    “Fluoroquinolones, including levofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions … Tendinitis and tendon rupture … Peripheral neuropathy … Central nervous system effects … may exacerbate muscle weakness in patients with myasthenia gravis”
  13. FDA DailyMed — Levofloxacin tablets, Drug Interactions · read 2026-08-27
    what it says
    “Warfarin Effect may be enhanced. Monitor prothrombin time, INR and watch for bleeding … Antidiabetic agents Carefully monitor blood glucose”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.