{"ok":true,"entry":{"slug":"levofloxacin","kind":"medication","name":"levofloxacin","aliases":["Cravit"],"brands_sg":["Cravit","Locikline","Lufi","Avatac","Levores"],"class":"fluoroquinolone antibiotic","tags":["antibiotic"],"use_for":"prescribed for bacterial infections — your doctor decides","use_after":"once daily, at the same time each day (sg leaflet)","use_duration":null,"take_with":"water · with or without food; 2 h apart from antacids","pros":["sg leaflet: with or without food","usually once a day for the listed infections","tablets, infusion and eye drops all registered in sg"],"cons":["boxed warning: tendon, nerve and cns reactions","can worsen myasthenia gravis — labels warn","sun sensitivity, nausea and diarrhoea are common"],"dose_note":"the singapore cravit tablet insert (SIN11632P) states \"The usual dose of CRAVIT ® Tablets is 250 mg or 500 mg administered orally, as indicated by infection\", and its renal-impairment table lists a 750 mg initial dose for complicated skin and skin structure infections; only 250 mg and 500 mg tablets are registered in singapore. the us label's ceiling is 750 mg \"Every 24 hours\" — \"Nosocomial Pneumonia … 750 mg\", \"Complicated SSSI … 750 mg\", \"Complicated UTI … 750 mg\" — against 250 mg for uncomplicated uti. as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["epilepsy or seizures — sg leaflet: tell your doctor","myasthenia gravis — sg leaflet and us boxed warning","heart-rhythm problems or heart-rhythm medicines","g6pd deficiency — sg leaflet: tell your doctor"],"clashes":[{"src":["hh_levo_avoid","ndf_cravit_dose"],"food":true,"note":"sg leaflet: 2 h before or after — absorption drops; cravit insert says two hours either side","with":"antacids, dairy, iron, calcium, zinc, sucralfate, binders"},{"src":["hh_levo_avoid"],"note":"sg leaflet lists nsaids among medicines that may raise side-effect risk","with":"nsaids"},{"src":["hh_levo_avoid"],"note":"sg leaflet: may raise the risk of levofloxacin side effects","with":"theophylline"},{"src":["fda_levo_int"],"note":"us label: effect may be enhanced — prothrombin time/inr monitored","with":"warfarin"},{"src":["fda_levo_int"],"note":"us label: blood glucose carefully monitored","with":"diabetes medicines"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset; filtered locally for levofloxacin)","quote":"Forensicclassification = 'Prescription Only' for all 19 levofloxacin rows (11 oral tablets, 6 infusions, 2 eye drops) — e.g. SIN11632P CRAVIT TABLET 500 mg; SIN13953P LOCIKLINE TABLETS 500MG; SIN11826P CRAVIT OPHTHALMIC SOLUTION 0.5% w/v","accessed":"2026-08-27"},{"id":"ndf_cravit_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11632p/","label":"MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], product information","quote":"LEVOFLOXACIN - 500 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_cravit_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11632p/","label":"MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], indications and usage","quote":"CRAVIT ® Tablets are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms","accessed":"2026-08-27"},{"id":"ndf_cravit_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11632p/","label":"MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], dosage and administration","quote":"The usual dose of CRAVIT ® Tablets is 250 mg or 500 mg administered orally, as indicated by infection … Oral doses should be administered at least two hours before or two hours after antacids containing magnesium, aluminum","accessed":"2026-08-27"},{"id":"ndf_cravit_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11632p/","label":"MOH National Drug Formulary — CRAVIT TABLET 500 MG [SIN11632P], contraindications","quote":"Levofloxacin is contraindicated in persons with a history of hypersensitivity to levofloxacin, quinolone antimicrobial agents, or any other components of this product.","accessed":"2026-08-27"},{"id":"hh_levo_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levofloxacin","label":"HealthHub (National Medication Information workgroup / Pharmaceutical Society of Singapore) — Levofloxacin, reviewed 31 May 2024","quote":"Levofloxacin is an antibiotic that is used to treat bacterial infections. These infections may include those of the lungs, bone, joints, skin, eyes and ears.","accessed":"2026-08-27"},{"id":"hh_levo_how","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levofloxacin","label":"HealthHub — Levofloxacin: how should I take or use this medication","quote":"You may take this medication with or without food. Take this medication at the same time each day. Complete the course of antibiotics as prescribed by your doctor.","accessed":"2026-08-27"},{"id":"hh_levo_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levofloxacin","label":"HealthHub — Levofloxacin: what precautions should I take","quote":"Inform your healthcare professional if: You have any other medical conditions such as: Epilepsy (fits or seizures) Myasthenia gravis … You have existing heart problems or are on any medicine that regulates your heartbeat … G6PD deficiency","accessed":"2026-08-27"},{"id":"hh_levo_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levofloxacin","label":"HealthHub — Levofloxacin: common and serious side effects","quote":"Nausea, vomiting or loss of appetite … Diarrhoea … Dizziness … Increased sensitivity to sunlight … Painful swelling of the joints or tendons … Seizures (fits)","accessed":"2026-08-27"},{"id":"hh_levo_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levofloxacin","label":"HealthHub — Levofloxacin: what food or medication should I avoid","quote":"Milk-containing products … Indigestion remedies (e.g. Antacids) … supplements that contain aluminium, calcium, iron, magnesium or zinc … 2 hours before or after Levofloxacin … NSAIDs Theophylline Cyclosporine Probenecid","accessed":"2026-08-27"},{"id":"fda_levo_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05d179f5-b200-8597-e063-6394a90a10cc","label":"FDA DailyMed — Levofloxacin tablets (NuCare Pharmaceuticals), Dosage & Administration, eff. 2025-03-04","quote":"Type of Infection Dose Every 24 hours Duration (days) Nosocomial Pneumonia 750 mg 7 to 14 … Complicated SSSI 750 mg 7 to 14 … Uncomplicated UTI 250 mg 3","accessed":"2026-08-27"},{"id":"fda_levo_boxed","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05d179f5-b200-8597-e063-6394a90a10cc","label":"FDA DailyMed — Levofloxacin tablets, Boxed Warning","quote":"Fluoroquinolones, including levofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions … Tendinitis and tendon rupture … Peripheral neuropathy … Central nervous system effects … may exacerbate muscle weakness in patients with myasthenia gravis","accessed":"2026-08-27"},{"id":"fda_levo_int","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05d179f5-b200-8597-e063-6394a90a10cc","label":"FDA DailyMed — Levofloxacin tablets, Drug Interactions","quote":"Warfarin Effect may be enhanced. Monitor prothrombin time, INR and watch for bleeding … Antidiabetic agents Carefully monitor blood glucose","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}