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Levetiracetam

Medication anticonvulsant other
Aka: Keppra
Brands seen in Singapore: Keppra, Intiracetam, Levera, Levipil, Epivon
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
HealthHub: control of seizures and related conditions
When to take
HealthHub: with or without food; SG label: two daily doses
Take with
Water for tablets · HealthHub: alcohol best avoided
Pros & cons
Pros
  • HealthHub: taken with or without food
  • SG label: iv and oral swap directly, without titration
  • SG label: monotherapy from 16 for partial seizures
Cons
  • HealthHub: dizziness, drowsiness, loose stools
  • HealthHub: mood, aggression or self-harm changes
  • HealthHub: rare severe skin reactions (sjs, ten, dress)
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 33 registered levetiracetam products read Forensicclassification 'Prescription Only' — SIN11685P KEPPRA TABLET 250 mg · SIN11686P KEPPRA TABLET 500 mg · SIN16291P INTIRACETAM · SIN16789P LEVERA 250 · SIN15665P LEVIPIL 250 · SIN14447P Epivon”
  2. HealthHub (National Medication Information workgroup, SG) — Levetiracetam: what is this medication for · read 2026-08-27
    what it says
    “Levetiracetam is used to control seizures and other conditions related to the nervous system.”
  3. HealthHub — Levetiracetam: how should I take this medication · read 2026-08-27
    what it says
    “You can take this medication with or without food. If you are taking the tablets, swallow the tablets with a glass of water … The oral solution may be diluted in some water before taking.”
  4. HealthHub — Levetiracetam: common side effects · read 2026-08-27
    what it says
    “The common side effects of Levetiracetam include: Dizziness; Drowsiness; Loose stools (diarrhoea); Nausea, vomiting; Headache; Loss of appetite; Neck pain, tingling or prickling sensation on skin”
  5. HealthHub — Levetiracetam: rare but serious side effects · read 2026-08-27
    what it says
    “Blistering, peeling, red skin rash due to Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN), Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) … Hallucinations …, depression, aggression, irritability”
  6. HealthHub — Levetiracetam: what precautions should I take · read 2026-08-27
    what it says
    “Inform your healthcare professionals if you have the following medical conditions before starting on levetiracetam: Kidney problems; Any symptoms of depression and/or suicidal ideation; Drug allergies … discuss with your doctor regarding family planning”
  7. HealthHub — Levetiracetam: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol while taking this medication.”
  8. Singapore National Drug Formulary (HSA/MOH) — KEPPRA TABLET 500 MG [SIN11686P], Indications · read 2026-08-27
    what it says
    “Keppra is indicated as monotherapy in the treatment of partial onset seizures with or without secondary generalisation in adults and adolescents from 16 years of age with newly diagnosed epilepsy.”
  9. Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], monotherapy dosing · read 2026-08-27
    what it says
    “The recommended starting dose is 250 mg twice daily which should be increased to an initial therapeutic dose of 500 mg twice daily after two weeks … The maximum dose is 1500 mg twice daily.”
  10. Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], add-on therapy dosing · read 2026-08-27
    what it says
    “The initial therapeutic dose is 500 mg twice daily … Depending upon the clinical response and tolerance, the daily dose can be increased up to 1,500 mg twice daily.”
  11. Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], route conversion · read 2026-08-27
    what it says
    “Keppra therapy can be initiated with either intravenous or oral administration. Conversion to or from oral to intravenous administration can be done directly without titration. The total daily dose and frequency of administration should be maintained.”
  12. Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], renal and hepatic impairment · read 2026-08-27
    what it says
    “The daily dose must be individualised according to renal function … In patients with severe hepatic impairment … a 50% reduction of the daily maintenance dose is recommended when the creatinine clearance is <60 ml/min/1.73 m2”
  13. Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], Contraindications · read 2026-08-27
    what it says
    “Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.