{"ok":true,"entry":{"slug":"levetiracetam","kind":"medication","name":"levetiracetam","aliases":["Keppra"],"brands_sg":["Keppra","Intiracetam","Levera","Levipil","Epivon"],"class":"anticonvulsant","tags":["other"],"use_for":"healthhub: control of seizures and related conditions","use_after":"healthhub: with or without food; sg label: two daily doses","use_duration":null,"take_with":"water for tablets · healthhub: alcohol best avoided","pros":["healthhub: taken with or without food","sg label: iv and oral swap directly, without titration","sg label: monotherapy from 16 for partial seizures"],"cons":["healthhub: dizziness, drowsiness, loose stools","healthhub: mood, aggression or self-harm changes","healthhub: rare severe skin reactions (sjs, ten, dress)"],"dose_note":"the singapore label for keppra tablet states, for monotherapy in adults and adolescents from 16 years, 'The maximum dose is 1500 mg twice daily', and for add-on therapy that 'the daily dose can be increased up to 1,500 mg twice daily' — 3,000 mg a day on either route. the same label requires the daily dose to be individualised according to renal function, and a 50% reduction of the daily maintenance dose in severe hepatic impairment when creatinine clearance is below 60 ml/min/1.73 m2. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["healthhub: kidney problems","healthhub: any symptoms of depression or suicidal ideation","healthhub: family planning, for women of child-bearing age","sg label: hypersensitivity to pyrrolidone derivatives"],"clashes":[{"src":["hh_lev_avoid"],"food":true,"note":"healthhub: avoid drinking alcohol while taking this medication","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 33 registered levetiracetam products read Forensicclassification 'Prescription Only' — SIN11685P KEPPRA TABLET 250 mg · SIN11686P KEPPRA TABLET 500 mg · SIN16291P INTIRACETAM · SIN16789P LEVERA 250 · SIN15665P LEVIPIL 250 · SIN14447P Epivon","accessed":"2026-08-27"},{"id":"hh_lev_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levetiracetam","label":"HealthHub (National Medication Information workgroup, SG) — Levetiracetam: what is this medication for","quote":"Levetiracetam is used to control seizures and other conditions related to the nervous system.","accessed":"2026-08-27"},{"id":"hh_lev_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levetiracetam","label":"HealthHub — Levetiracetam: how should I take this medication","quote":"You can take this medication with or without food. If you are taking the tablets, swallow the tablets with a glass of water … The oral solution may be diluted in some water before taking.","accessed":"2026-08-27"},{"id":"hh_lev_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levetiracetam","label":"HealthHub — Levetiracetam: common side effects","quote":"The common side effects of Levetiracetam include: Dizziness; Drowsiness; Loose stools (diarrhoea); Nausea, vomiting; Headache; Loss of appetite; Neck pain, tingling or prickling sensation on skin","accessed":"2026-08-27"},{"id":"hh_lev_rare","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levetiracetam","label":"HealthHub — Levetiracetam: rare but serious side effects","quote":"Blistering, peeling, red skin rash due to Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN), Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) … Hallucinations …, depression, aggression, irritability","accessed":"2026-08-27"},{"id":"hh_lev_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levetiracetam","label":"HealthHub — Levetiracetam: what precautions should I take","quote":"Inform your healthcare professionals if you have the following medical conditions before starting on levetiracetam: Kidney problems; Any symptoms of depression and/or suicidal ideation; Drug allergies … discuss with your doctor regarding family planning","accessed":"2026-08-27"},{"id":"hh_lev_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/levetiracetam","label":"HealthHub — Levetiracetam: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking this medication.","accessed":"2026-08-27"},{"id":"ndf_kep_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11686p/","label":"Singapore National Drug Formulary (HSA/MOH) — KEPPRA TABLET 500 MG [SIN11686P], Indications","quote":"Keppra is indicated as monotherapy in the treatment of partial onset seizures with or without secondary generalisation in adults and adolescents from 16 years of age with newly diagnosed epilepsy.","accessed":"2026-08-27"},{"id":"ndf_kep_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11686p/","label":"Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], monotherapy dosing","quote":"The recommended starting dose is 250 mg twice daily which should be increased to an initial therapeutic dose of 500 mg twice daily after two weeks … The maximum dose is 1500 mg twice daily.","accessed":"2026-08-27"},{"id":"ndf_kep_addon","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11686p/","label":"Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], add-on therapy dosing","quote":"The initial therapeutic dose is 500 mg twice daily … Depending upon the clinical response and tolerance, the daily dose can be increased up to 1,500 mg twice daily.","accessed":"2026-08-27"},{"id":"ndf_kep_iv","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11686p/","label":"Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], route conversion","quote":"Keppra therapy can be initiated with either intravenous or oral administration. Conversion to or from oral to intravenous administration can be done directly without titration. The total daily dose and frequency of administration should be maintained.","accessed":"2026-08-27"},{"id":"ndf_kep_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11686p/","label":"Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], renal and hepatic impairment","quote":"The daily dose must be individualised according to renal function … In patients with severe hepatic impairment … a 50% reduction of the daily maintenance dose is recommended when the creatinine clearance is <60 ml/min/1.73 m2","accessed":"2026-08-27"},{"id":"ndf_kep_ci","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin11686p/","label":"Singapore National Drug Formulary — KEPPRA TABLET 500 MG [SIN11686P], Contraindications","quote":"Hypersensitivity to the active substance or other pyrrolidone derivatives or to any of the excipients.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}