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Lactoferrin

Supplement milk protein immunegut
Aka: apolactoferrin, bovine lactoferrin
Brands seen in Singapore: Jarrow Formulas, Best Naturals, Life Extension, Nutricost, Humanx
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Immune and gut symptoms — human evidence is limited
When to take
No timing rule reported
Studied for
Trials ran about 12 weeks
Pros & cons
Pros
  • Review: 200 mg/day reduced systemic inflammation
  • 12-week RCT: fewer acute gut symptoms in daycare staff
  • Better serum iron and haemoglobin than ferrous sulfate
Cons
  • Respiratory infections fell in children, not in adults
  • The review calls clinical studies on it limited
  • Most of the gut evidence is one trial in one workplace
Sources
  1. Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis (Advances in Nutrition, 2022) — abstract via Europe PMC REST, PMC9526865 · read 2026-08-27
    what it says
    “RTI incidence was reduced in infants and children (OR: 0.78; 95% CI: 0.61, 0.98) but not in adults (OR: 1.00; 95% CI: 0.76, 1.32). Clinical studies on Lf supplementation are limited, although findings show 200 mg Lf/d reduces systemic inflammation”
  2. Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial (Mizuki et al., Int J Environ Res Public Health 2020) — abstract via Europe PMC REST, PMC7767418 · read 2026-08-27
    what it says
    “the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF … than in the Placebo group”
  3. Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials (Nutrients, 2022) — abstract via Europe PMC REST, PMC8838920 · read 2026-08-27
    what it says
    “Lactoferrin supplementation had better effects on serum iron … ferritin … and hemoglobin concentration … but a reducing effect on fractional iron absorption … compared with ferrous sulfate”
  4. HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 (Tables 4–5 list vitamins and minerals only; no lactoferrin row) · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5”
  5. HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3; Annexes A and B checked · read 2026-08-27
    what it says
    “highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [lactoferrin, milk protein and bovine-derived ingredients are not listed in Annex A or B]”
  6. iHerb Singapore — “Lactoferrin Supplements” category page, default order, 13 results · read 2026-08-27
    what it says
    “Jarrow Formulas, Lactoferrin, Freeze Dried, 250 mg … Best Naturals, Lactoferrin, 250 mg … Life Extension, Lactoferrin Caps … Nutricost, Lactoferrin, 300 mg … Humanx, Lactoferrin, 500 mg”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.