{"ok":true,"entry":{"slug":"lactoferrin","kind":"supplement","name":"lactoferrin","aliases":["apolactoferrin","bovine lactoferrin"],"brands_sg":["Jarrow Formulas","Best Naturals","Life Extension","Nutricost","Humanx"],"class":"milk protein","tags":["immune","gut"],"use_for":"immune and gut symptoms — human evidence is limited","use_after":"no timing rule reported","use_duration":"trials ran about 12 weeks","take_with":null,"pros":["review: 200 mg/day reduced systemic inflammation","12-week RCT: fewer acute gut symptoms in daycare staff","better serum iron and haemoglobin than ferrous sulfate"],"cons":["respiratory infections fell in children, not in adults","the review calls clinical studies on it limited","most of the gut evidence is one trial in one workplace"],"dose_note":"the 2022 review reports 200 mg a day reducing systemic inflammation and formulas of 35–833 mg a day in infants and children; the gut trial used 200 mg and 600 mg a day for 12 weeks","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["milk allergy — lactoferrin is a glycoprotein present in human and bovine milk","adults — the pooled drop in respiratory-infection incidence was in infants and children only","iron-deficiency anaemia — the trials compared it against ferrous sulfate, under medical care"],"clashes":[],"sources":[{"id":"lf_advnutr","url":"https://europepmc.org/article/PMC/PMC9526865","label":"Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis (Advances in Nutrition, 2022) — abstract via Europe PMC REST, PMC9526865","quote":"RTI incidence was reduced in infants and children (OR: 0.78; 95% CI: 0.61, 0.98) but not in adults (OR: 1.00; 95% CI: 0.76, 1.32). Clinical studies on Lf supplementation are limited, although findings show 200 mg Lf/d reduces systemic inflammation","accessed":"2026-08-27"},{"id":"lf_gi_rct","url":"https://europepmc.org/article/PMC/PMC7767418","label":"Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial (Mizuki et al., Int J Environ Res Public Health 2020) — abstract via Europe PMC REST, PMC7767418","quote":"the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF … than in the Placebo group","accessed":"2026-08-27"},{"id":"lf_iron","url":"https://europepmc.org/article/PMC/PMC8838920","label":"Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials (Nutrients, 2022) — abstract via Europe PMC REST, PMC8838920","quote":"Lactoferrin supplementation had better effects on serum iron … ferritin … and hemoglobin concentration … but a reducing effect on fractional iron absorption … compared with ferrous sulfate","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 (Tables 4–5 list vitamins and minerals only; no lactoferrin row)","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3; Annexes A and B checked","quote":"highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [lactoferrin, milk protein and bovine-derived ingredients are not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/lactoferrin","label":"iHerb Singapore — “Lactoferrin Supplements” category page, default order, 13 results","quote":"Jarrow Formulas, Lactoferrin, Freeze Dried, 250 mg … Best Naturals, Lactoferrin, 250 mg … Life Extension, Lactoferrin Caps … Nutricost, Lactoferrin, 300 mg … Humanx, Lactoferrin, 500 mg","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}