Lactobacillus plantarum
Supplement
probiotic
gut
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
IBS — abdominal pain and bloating in one large trial
Take with
One capsule a day was the whole 299v trial regimen
Studied for
The 299v trial measured symptoms weekly over 4 weeks
Pros & cons
Pros
- Pain severity and frequency beat placebo at 4 weeks
- 214 IBS patients (rome iii) in one randomised trial
- IBS reviews find probiotics may help global symptoms
Cons
- Reviews cannot yet say which strains work best
- The trial tested one strain, 299v (dsm 9843)
- Nothing beyond 4 weeks was measured in that trial
Sources
- NIH NCCIH — Probiotics: Usefulness and Safety · read 2026-08-27
what it says
“probiotics may have beneficial effects on global IBS symptoms and abdominal pain, but it was not possible … to identify which species, strains, or combinations of probiotics are most likely to be helpful”
- NIH NCCIH — Probiotics: Usefulness and Safety, "Can probiotics be harmful?" · read 2026-08-27
what it says
“The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … Cases of severe or fatal infections have been reported in premature infants who were given probiotics”
- Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome (Ducrotté et al., World J Gastroenterol 2012) · read 2026-08-27
what it says
“subjects were randomized to daily receive either one capsule of L. plantarum 299v (DSM 9843) or placebo for 4 wk … Two hundred and fourteen IBS patients were recruited … both pain severity … and daily frequency … were lower”
- iHerb Singapore — Probiotics category page (default best-selling order) · read 2026-08-27
what it says
“California Gold Nutrition, LactoBif® 30 Probiotics, 60 Veggie Capsules”
- HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B · read 2026-08-27
what it says
“The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
- HSA — Health Supplements Guidelines (Jan 2026), working definition and Tables 4–5 · read 2026-08-27
what it says
“Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … Table 4: Vitamins Limits … Table 5: Minerals Limits”
Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.