{"ok":true,"entry":{"slug":"lactobacillus-plantarum","kind":"supplement","name":"lactobacillus plantarum","aliases":["L. plantarum","Lactiplantibacillus plantarum"],"brands_sg":["California Gold Nutrition","21st Century","Garden of Life","NOW Foods","Lemme"],"class":"probiotic","tags":["gut"],"use_for":"ibs — abdominal pain and bloating in one large trial","use_after":null,"use_duration":"the 299v trial measured symptoms weekly over 4 weeks","take_with":"one capsule a day was the whole 299v trial regimen","pros":["pain severity and frequency beat placebo at 4 weeks","214 ibs patients (rome iii) in one randomised trial","ibs reviews find probiotics may help global symptoms"],"cons":["reviews cannot yet say which strains work best","the trial tested one strain, 299v (dsm 9843)","nothing beyond 4 weeks was measured in that trial"],"dose_note":"the ibs trial used one capsule of 299v (dsm 9843) a day for 4 weeks; the abstract does not state a cfu count","dosage":{"ul":null,"unit":"CFU","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["severe illness or weakened immunity — higher risk of harm","premature infants — fda warned of severe or fatal infections"],"clashes":[],"sources":[{"id":"nccih_probiotics","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety","quote":"probiotics may have beneficial effects on global IBS symptoms and abdominal pain, but it was not possible … to identify which species, strains, or combinations of probiotics are most likely to be helpful","accessed":"2026-08-27"},{"id":"nccih_safety","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety, \"Can probiotics be harmful?\"","quote":"The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … Cases of severe or fatal infections have been reported in premature infants who were given probiotics","accessed":"2026-08-27"},{"id":"ducrotte2012","url":"https://europepmc.org/article/MED/22912552","label":"Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome (Ducrotté et al., World J Gastroenterol 2012)","quote":"subjects were randomized to daily receive either one capsule of L. plantarum 299v (DSM 9843) or placebo for 4 wk … Two hundred and fourteen IBS patients were recruited … both pain severity … and daily frequency … were lower","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/probiotics","label":"iHerb Singapore — Probiotics category page (default best-selling order)","quote":"California Gold Nutrition, LactoBif® 30 Probiotics, 60 Veggie Capsules","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), working definition and Tables 4–5","quote":"Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … Table 4: Vitamins Limits … Table 5: Minerals Limits","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Garden of Life","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":23},{"brand":"Lemme","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}