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Lactobacillus casei

Supplement probiotic gut
Aka: L. casei, L. paracasei, Lacticaseibacillus casei
Brands seen in Singapore: California Gold Nutrition, 21st Century, Garden of Life, NOW Foods, Lemme
Third-party tested: Garden of Life, Lemme certify other products with NSF Certified for Sport, but nothing for lactobacillus casei.Certification is granted per product, so check the tub you actually own. Not being listed is not the same as failing.
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Bloating in IBS · pain and global IBS scores: no effect
When to take
Daily
Take with
Water or a fermented milk drink — the trial format
Studied for
Trials ran from 4 weeks to 6 months
Pros & cons
Pros
  • Abdominal distension improved in an IBS meta-analysis
  • Shirota was safe over 6 months in early cirrhosis
  • Long food history in fermented milk drinks
Cons
  • Shirota missed on IBS in a 2026 strain-level review
  • No effect on IBS pain in a 10-RCT meta-analysis
  • Dyspepsia data is one 55-person pilot, no inert placebo
Sources
  1. NIH ODS — Probiotics Fact Sheet for Health Professionals — Irritable bowel syndrome (strains without effect; distension) · read 2026-08-27
    what it says
    “Streptococcus salivarius ssp. thermophilus, Bifidobacterium animalis, Bifidobacterium infantis, Lactobacillus casei, Lactobacillus plantarum … had no significant effect … abdominal distension scores improved with … Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum”
  2. NIH ODS — Probiotics Fact Sheet for Health Professionals — Identification / Mechanisms of action (read via archive.org; ods.od.nih.gov is Cloudflare-blocked) · read 2026-08-27
    what it says
    “Because the effects of probiotics can be specific to certain probiotic strains, recommendations for their use in the clinic need to be strain-specific … Probiotics may transiently colonize the human gut mucosa in highly individualized patterns”
  3. NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (CFU labelling, shelf life) · read 2026-08-27
    what it says
    “Many probiotic supplements contain 1 to 10 billion CFU per dose, but some products contain 50 billion CFU or more. However, products with higher CFU counts are not necessarily more effective”
  4. NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (viability at end of shelf life) · read 2026-08-27
    what it says
    “probiotics must be consumed alive … users should look for products labeled with the number of CFU at the end of the product's shelf life, not at the time of manufacture”
  5. NIH ODS — Probiotics Fact Sheet for Health Professionals — Safety Considerations · read 2026-08-27
    what it says
    “Probiotics are unlikely to cause harm in healthy people, and side effects are usually minor … linked to a few cases of bacteremia, fungemia, and infections … most of these cases involved individuals who were severely ill or immunocompromised”
  6. NIH NCCIH — Probiotics: Usefulness and Safety — What types of bacteria are in probiotics? · read 2026-08-27
    what it says
    “Different types of probiotics may have different effects. For example, if a specific kind of Lactobacillus helps prevent an illness, that doesn't necessarily mean that another kind of Lactobacillus … would do the same thing”
  7. NIH NCCIH — Probiotics: Usefulness and Safety — Can probiotics be harmful? / FDA 2023 preterm warning · read 2026-08-27
    what it says
    “The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … the FDA warned health care providers that premature infants who are given probiotics are at risk of severe, potentially fatal infections”
  8. Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome (Maslennikov et al., J Clin Med 2026; 32 RCTs, 10 strains) · read 2026-08-27
    what it says
    “Meta-analyses demonstrated the efficacy of Bifidobacterium longum (formerly Bifidobacterium infantis) 35624 … and Bacillus coagulans Unique IS2 (MTCC 5260) … did not demonstrate the efficacy of Escherichia coli Nissle 1917, Lactobacillus gasseri BNR17, or Lactobacillus casei Shirota”
  9. A Double-Blind, Randomized Placebo-Controlled Trial of Probiotic Lactobacillus casei Shirota in Stable Cirrhotic Patients (Nutrients 2020; n=92) · read 2026-08-27
    what it says
    “92 cirrhotic patients … randomized to receive LcS or placebo, three times daily for six months … Rates of infection, decompensation or neutrophil function did not differ … LcS supplementation in patients with early cirrhosis is safe”
  10. Intervention With Lacticaseibacillus paracasei PC-01 Fermented Milk Beverage Ameliorates Functional Dyspepsia: A Pilot Study (Food Sci Nutr 2026; n=55) · read 2026-08-27
    what it says
    “the PC-01 fermented milk beverage (5.0 x 10^8 CFU/mL, 200 mL/day) … 28 days … the limitation of this pilot study is that the acidified milk beverage used as the control might also exert certain effects on gastrointestinal symptoms”
  11. HSA — Health Supplements Guidelines (January 2026), s3.1 working definition; Table 2 microbial limits; Tables 4–5 cover vitamins and minerals only · read 2026-08-27
    what it says
    “Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … The above limits for total aerobic microbial count, and yeast and mould may not be applicable to certain products such as probiotics”
  12. HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B · read 2026-08-27
    what it says
    “to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [no probiotic, Lactobacillus, Bifidobacterium, Bacillus or Akkermansia row appears in Annex A or B]”
  13. iHerb Singapore — 'Probiotic Supplements for Gut Health' category page, default order (page now Cloudflare-blocked; row carried over from the KB's probiotics entry, same access date) · read 2026-08-27
    what it says
    “California Gold Nutrition, LactoBif® 30 Probiotics … 21st Century, Cranberry Plus Probiotic … Garden of Life, Dr. Formulated Probiotics, Once Daily Women's, 50 Billion … NOW Foods, Probiotic-10™ … Lemme, Purr, Vaginal Probiotic Gummies”
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Updated 2026-08-30. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.