{"ok":true,"entry":{"slug":"lactobacillus-casei","kind":"supplement","name":"lactobacillus casei","aliases":["L. casei","L. paracasei","Lacticaseibacillus casei"],"brands_sg":["California Gold Nutrition","21st Century","Garden of Life","NOW Foods","Lemme"],"class":"probiotic","tags":["gut"],"use_for":"bloating in ibs · pain and global ibs scores: no effect","use_after":"daily","use_duration":"trials ran from 4 weeks to 6 months","take_with":"water or a fermented milk drink — the trial format","pros":["abdominal distension improved in an ibs meta-analysis","shirota was safe over 6 months in early cirrhosis","long food history in fermented milk drinks"],"cons":["shirota missed on ibs in a 2026 strain-level review","no effect on ibs pain in a 10-rct meta-analysis","dyspepsia data is one 55-person pilot, no inert placebo"],"dose_note":"trials use a fermented milk drink: 5 x 10^8 cfu/ml, 200 ml a day for 28 days of l. paracasei pc-01 in functional dyspepsia, and l. casei shirota three times a day for six months in cirrhosis; no rda, ul or fda dv exists for live microorganisms; hsa sets no daily limit and no lactobacillus appears on its prohibited/restricted annexes","dosage":{"ul":null,"unit":"CFU/day","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["severely ill or immunocompromised — bacteremia and fungemia reported; ask your doctor first","preterm infants — fda warns of severe, potentially fatal infection; a hospital decision only","in intensive care or with a central line — the reported cases cluster there; ask your doctor"],"clashes":[],"sources":[{"id":"nih_ods_prob_ibs_neg","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Irritable bowel syndrome (strains without effect; distension)","quote":"Streptococcus salivarius ssp. thermophilus, Bifidobacterium animalis, Bifidobacterium infantis, Lactobacillus casei, Lactobacillus plantarum … had no significant effect … abdominal distension scores improved with … Bifidobacterium infantis, Lactobacillus casei, or Lactobacillus plantarum","accessed":"2026-08-27"},{"id":"nih_ods_prob_strain","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Identification / Mechanisms of action (read via archive.org; ods.od.nih.gov is Cloudflare-blocked)","quote":"Because the effects of probiotics can be specific to certain probiotic strains, recommendations for their use in the clinic need to be strain-specific … Probiotics may transiently colonize the human gut mucosa in highly individualized patterns","accessed":"2026-08-27"},{"id":"nih_ods_prob_cfu","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (CFU labelling, shelf life)","quote":"Many probiotic supplements contain 1 to 10 billion CFU per dose, but some products contain 50 billion CFU or more. However, products with higher CFU counts are not necessarily more effective","accessed":"2026-08-27"},{"id":"nih_ods_prob_shelf","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (viability at end of shelf life)","quote":"probiotics must be consumed alive … users should look for products labeled with the number of CFU at the end of the product's shelf life, not at the time of manufacture","accessed":"2026-08-27"},{"id":"nih_ods_prob_safety","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Safety Considerations","quote":"Probiotics are unlikely to cause harm in healthy people, and side effects are usually minor … linked to a few cases of bacteremia, fungemia, and infections … most of these cases involved individuals who were severely ill or immunocompromised","accessed":"2026-08-27"},{"id":"nccih_prob_types","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety — What types of bacteria are in probiotics?","quote":"Different types of probiotics may have different effects. For example, if a specific kind of Lactobacillus helps prevent an illness, that doesn't necessarily mean that another kind of Lactobacillus … would do the same thing","accessed":"2026-08-27"},{"id":"nccih_prob_harm","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety — Can probiotics be harmful? / FDA 2023 preterm warning","quote":"The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … the FDA warned health care providers that premature infants who are given probiotics are at risk of severe, potentially fatal infections","accessed":"2026-08-27"},{"id":"ibs_sr2026","url":"https://europepmc.org/article/PMC/PMC12898053","label":"Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome (Maslennikov et al., J Clin Med 2026; 32 RCTs, 10 strains)","quote":"Meta-analyses demonstrated the efficacy of Bifidobacterium longum (formerly Bifidobacterium infantis) 35624 … and Bacillus coagulans Unique IS2 (MTCC 5260) … did not demonstrate the efficacy of Escherichia coli Nissle 1917, Lactobacillus gasseri BNR17, or Lactobacillus casei Shirota","accessed":"2026-08-27"},{"id":"lcs_cirrhosis2020","url":"https://europepmc.org/article/PMC/PMC7352321","label":"A Double-Blind, Randomized Placebo-Controlled Trial of Probiotic Lactobacillus casei Shirota in Stable Cirrhotic Patients (Nutrients 2020; n=92)","quote":"92 cirrhotic patients … randomized to receive LcS or placebo, three times daily for six months … Rates of infection, decompensation or neutrophil function did not differ … LcS supplementation in patients with early cirrhosis is safe","accessed":"2026-08-27"},{"id":"pc01_dyspepsia2026","url":"https://europepmc.org/article/PMC/PMC13322318","label":"Intervention With Lacticaseibacillus paracasei PC-01 Fermented Milk Beverage Ameliorates Functional Dyspepsia: A Pilot Study (Food Sci Nutr 2026; n=55)","quote":"the PC-01 fermented milk beverage (5.0 x 10^8 CFU/mL, 200 mL/day) … 28 days … the limitation of this pilot study is that the acidified milk beverage used as the control might also exert certain effects on gastrointestinal symptoms","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (January 2026), s3.1 working definition; Table 2 microbial limits; Tables 4–5 cover vitamins and minerals only","quote":"Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … The above limits for total aerobic microbial count, and yeast and mould may not be applicable to certain products such as probiotics","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B","quote":"to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [no probiotic, Lactobacillus, Bifidobacterium, Bacillus or Akkermansia row appears in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/probiotics","label":"iHerb Singapore — 'Probiotic Supplements for Gut Health' category page, default order (page now Cloudflare-blocked; row carried over from the KB's probiotics entry, same access date)","quote":"California Gold Nutrition, LactoBif® 30 Probiotics … 21st Century, Cranberry Plus Probiotic … Garden of Life, Dr. Formulated Probiotics, Once Daily Women's, 50 Billion … NOW Foods, Probiotic-10™ … Lemme, Purr, Vaginal Probiotic Gummies","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Garden of Life","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":23},{"brand":"Lemme","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:39.960259+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}