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Ipratropium

Medication short-acting antimuscarinic bronchodilator respiratory
Aka: Atrovent
Brands seen in Singapore: Berodual, Atrovent, Combivent, Steri-Neb Ipratropium, Iprovent
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Medlineplus: wheeze and breathlessness in copd
When to take
SG label: nebuliser 3–4 times daily; inhaler 4 times daily
Take with
Inhaled · SG label: can be combined with a beta-agonist
Pros & cons
Pros
  • Medlineplus: relaxes and opens the airways
  • SG label: maintenance treatment in copd and bronchitis
  • SG label: nebuliser solution or metered-dose inhaler
Cons
  • US label: not for the initial treatment of an attack
  • Medlineplus: dry mouth and difficulty passing urine
  • US label: spray in the eye risks narrow-angle glaucoma
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 5 registered ipratropium-containing products read 'Prescription Only' — ATROVENT SOLUTION 0.025% · STERI-NEB IPRATROPIUM 250 mcg/ml · IPROVENT INHALER 20 mcg/puff · BERODUAL SOLUTION (with fenoterol) · COMBIVENT UNIT DOSE VIAL (with salbutamol)”
  2. National Drug Formulary (SG, MOH) — ATROVENT SOLUTION 0.025% [SIN02815P], approved indications and posology · read 2026-08-27
    what it says
    “a total daily dose of 12 puffs should generally not be exceeded … Adults (including elderly) and adolescents over 12 years of age: 2.0 mL (40 drops = 0.5 mg ipratropium bromide anhydrous) 3 to 4 times daily”
  3. MedlinePlus (NIH/AHFS) — Ipratropium Oral Inhalation · read 2026-08-27
    what it says
    “used to prevent wheezing, shortness of breath, coughing, and chest tightness in people with chronic obstructive pulmonary disease … It works by relaxing and opening the air passages to the lungs”
  4. US FDA label — ATROVENT HFA (Boehringer Ingelheim), section 2 Dosage and Administration, via openFDA · read 2026-08-27
    what it says
    “The usual starting dosage of ATROVENT HFA is two inhalations four times a day … the total number of inhalations should not exceed 12 in 24 hours”
  5. US FDA label — ATROVENT HFA, section 5 Warnings and Precautions, via openFDA · read 2026-08-27
    what it says
    “Not indicated for the initial treatment of acute episodes of bronchospasm where rescue therapy is required for rapid response … Use with caution in patients with narrow-angle glaucoma … prostatic hyperplasia or bladder-neck obstruction”
  6. US FDA label — ATROVENT HFA, section 7 Drug Interactions, via openFDA · read 2026-08-27
    what it says
    “Anticholinergics: May interact additively with concomitantly used anticholinergic medications. Avoid administration of ATROVENT HFA with other anticholinergic-containing drugs”
  7. US FDA label — ipratropium bromide inhalation solution 0.02% (Chartwell RX), Dosage and Administration, via openFDA · read 2026-08-27
    what it says
    “The usual dosage … is 500 mcg (1 Unit-Dose Vial) administered three to four times a day by oral nebulization, with doses 6 to 8 hours apart … safety … when mixed with other drugs [is] not established”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.