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Inositol hexanicotinate

Supplement vitamin B3 form heart & metabolic
Aka: flush-free niacin, no-flush niacin
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
A flush-free niacin form — absorption is ~30% lower
Pros & cons
Pros
  • Labelled flush free — it does not cause flushing
  • Nicotinic acid flushing starts around 30–50 mg
Cons
  • Niacin absorption averages 30% below nicotinic acid
  • ODS cites a paper calling it 'benefit-free'
  • SG caps nicotinic acid in supplements at 15 mg/day
Sources
  1. NIH ODS — Niacin (Health Professional), dietary supplement forms · read 2026-08-27
    what it says
    “Niacin supplements are also available in the form of inositol hexanicotinate … The absorption of niacin from inositol hexanicotinate varies widely but on average is 30% lower than from nicotinic acid or nicotinamide”
  2. NIH ODS — Niacin (Health Professional), Tables 1 and 3 (RDA and UL) · read 2026-08-27
    what it says
    “Table 1: Recommended Dietary Allowances (RDAs) for Niacin … 19+ years 16 mg NE 14 mg NE … Table 3: Tolerable Upper Intake Levels (ULs) for Niacin … 19+ years 35 mg 35 mg”
  3. NIH ODS — Niacin (Health Professional), FDA Daily Value · read 2026-08-27
    what it says
    “The DV for niacin is 16 mg for adults and children age 4 years and older”
  4. NIH ODS — Niacin (Health Professional), Health Risks from Excessive Niacin · read 2026-08-27
    what it says
    “Thirty to 50 mg or more nicotinic acid typically causes flushing … High doses of nicotinic acid taken over months or years can also be hepatotoxic … impaired glucose tolerance and insulin resistance”
  5. NIH ODS — Niacin (Health Professional), reference list · read 2026-08-27
    what it says
    “Norris RB. “Flush-free niacin”: Dietary supplement may be “benefit-free.” Preventive Cardiology 2006;9:64-5.”
  6. HSA — Health Supplements Guidelines (Jan 2026), Table 4 vitamin limits · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Nicotinic acid 15mg … Nicotinamide 450mg”
  7. HSA — Health Supplements Guidelines (Jan 2026), Tables 4 & 5 vitamin/mineral limits · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  8. HSA — Health Supplements Guidelines (Jan 2026), Table 6 prohibited claims · read 2026-08-27
    what it says
    “HS must not be labelled, advertised or promoted for any specific medicinal purpose … Blood and circulatory system: Hypertension, stroke, cholesterol disorders, reduces cholesterol, regulates platelet aggregation”
  9. HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B · read 2026-08-27
    what it says
    “A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers should continue to: Conduct thorough safety assessments of their products”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.