{"ok":true,"entry":{"slug":"inositol-hexanicotinate","kind":"supplement","name":"inositol hexanicotinate","aliases":["flush-free niacin","no-flush niacin"],"brands_sg":[],"class":"vitamin B3 form","tags":["heart"],"use_for":"a flush-free niacin form — absorption is ~30% lower","use_after":null,"use_duration":null,"take_with":null,"pros":["labelled flush free — it does not cause flushing","nicotinic acid flushing starts around 30–50 mg"],"cons":["niacin absorption averages 30% below nicotinic acid","ODS cites a paper calling it 'benefit-free'","SG caps nicotinic acid in supplements at 15 mg/day"],"dose_note":"the adult niacin RDA is 16 mg NE for men and 14 mg NE for women, the FNB's 35 mg UL applies to supplemental niacin, and the FDA Daily Value is 16 mg; ODS gives no dose figure specific to inositol hexanicotinate","dosage":{"ul":35,"unit":"mg","fda_dv":16,"rda_ai":16,"ul_status":"established","population":"adults 19+ (RDA 16 mg NE men, 14 mg NE women)","hsa_max_daily":null},"ul_status":"established","sg_class":null,"cautions":["liver conditions — high-dose nicotinic acid can be hepatotoxic","diabetes — pharmacologic nicotinic acid doses impair glucose tolerance"],"clashes":[],"sources":[{"id":"ods_niacin","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional), dietary supplement forms","quote":"Niacin supplements are also available in the form of inositol hexanicotinate … The absorption of niacin from inositol hexanicotinate varies widely but on average is 30% lower than from nicotinic acid or nicotinamide","accessed":"2026-08-27"},{"id":"ods_niacin_dri","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional), Tables 1 and 3 (RDA and UL)","quote":"Table 1: Recommended Dietary Allowances (RDAs) for Niacin … 19+ years 16 mg NE 14 mg NE … Table 3: Tolerable Upper Intake Levels (ULs) for Niacin … 19+ years 35 mg 35 mg","accessed":"2026-08-27"},{"id":"ods_niacin_dv","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional), FDA Daily Value","quote":"The DV for niacin is 16 mg for adults and children age 4 years and older","accessed":"2026-08-27"},{"id":"ods_niacin_safety","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional), Health Risks from Excessive Niacin","quote":"Thirty to 50 mg or more nicotinic acid typically causes flushing … High doses of nicotinic acid taken over months or years can also be hepatotoxic … impaired glucose tolerance and insulin resistance","accessed":"2026-08-27"},{"id":"ods_niacin_refs","url":"https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/","label":"NIH ODS — Niacin (Health Professional), reference list","quote":"Norris RB. “Flush-free niacin”: Dietary supplement may be “benefit-free.” Preventive Cardiology 2006;9:64-5.","accessed":"2026-08-27"},{"id":"hsa_hs_b3","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Table 4 vitamin limits","quote":"Table 4: Vitamins Limits … Nicotinic acid 15mg … Nicotinamide 450mg","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4 & 5 vitamin/mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_hs_claims","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Table 6 prohibited claims","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose … Blood and circulatory system: Hypertension, stroke, cholesterol disorders, reduces cholesterol, regulates platelet aggregation","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B","quote":"A list of specific prohibited and restricted ingredients is provided in Annex A … This list is not exhaustive. Dealers should continue to: Conduct thorough safety assessments of their products","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}