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Inositol

Supplement vitamin-like compound women's healthsleep
Aka: myo-inositol, D-chiro-inositol, vitamin B8
Brands seen in Singapore: California Gold Nutrition, Nutricost, NOW Foods, Fairhaven Health, Wholesome Story
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Pcos — androgens, insulin resistance and ovulation rates
When to take
Daily
Take with
Folic acid · mi+fa did better than other forms
Pros & cons
Pros
  • Moderate-quality evidence for testosterone and homa-ir
  • Ovulation rate rr 2.75; live births rr 2.29 vs placebo
  • Fewer gi adverse events than metformin in the review
Cons
  • No high-quality evidence; 41% of items rated very low
  • Vs metformin, most outcomes showed no difference
  • Sleep data: one 10-week trial in 56 pregnant women
Sources
  1. Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials (Front Endocrinol 2026) — pooled outcomes · read 2026-08-27
    what it says
    “it reduced serum luteinizing hormone … total testosterone (TT), free testosterone … improved sex hormone-binding globulin … HOMA-IR … and reproductive outcomes (live births: Risk Ratio [RR] 2.29 … ovulation rate: RR 2.75)”
  2. Front Endocrinol 2026 umbrella review — evidence quality · read 2026-08-27
    what it says
    “GRADE assessment of 85 evidence items revealed no high-quality evidence; 18.9% were moderate, 40% low, and 41.1% very low quality”
  3. Front Endocrinol 2026 umbrella review — conclusion · read 2026-08-27
    what it says
    “Supported by moderate-quality evidence for effects on TT, FT, SHBG, HOMA-IR, and pregnancy/ovulation rates, it is a promising therapy … outcomes based on low-quality evidence require cautious interpretation”
  4. Front Endocrinol 2026 umbrella review — inositol subtypes · read 2026-08-27
    what it says
    “Cross-subgroup analysis of inositol subtypes indicated MI/MI+FA was superior for metabolic and reproductive outcomes, while D-chiro-inositol monotherapy should be used with caution in clinical practice”
  5. Front Endocrinol 2026 umbrella review — clinical implications (recommended dosage) · read 2026-08-27
    what it says
    “Based on effective doses reported in the majority of included studies, a daily intake of 2-4g of inositol is suggested for women with PCOS, preferably in combination with folic acid (e.g., MI+FA)”
  6. Front Endocrinol 2026 umbrella review — safety versus metformin · read 2026-08-27
    what it says
    “compared to MET, which commonly causes gastrointestinal adverse reactions, inositol demonstrates a lower risk of adverse events”
  7. Front Endocrinol 2026 umbrella review — mechanism and endogenous synthesis · read 2026-08-27
    what it says
    “MI enhances insulin sensitivity, aiding PCOS patients in restoring ovulation and hormonal balance”
  8. Front Endocrinol 2026 umbrella review — what inositol is · read 2026-08-27
    what it says
    “Inositol, a naturally occurring carbohydrate of the sugar alcohol class, contributes to glucose metabolism … the human body can synthesize approximately 4 grams daily through endogenous pathways (primarily in the kidneys)”
  9. Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review (Nutrition Reviews 2026) — myoinositol section · read 2026-08-27
    what it says
    “received either 2000 mg of myoinositol … or placebo … every night, 1 hour prior to bedtime, for 10 weeks. Postintervention, subjective sleep quality, sleep duration, and sleep efficiency were significantly increased … no objective sleep assessment was conducted”
  10. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list”
  11. iHerb Singapore — Inositol category (default order); first 5 distinct brands in page order: California Gold Nutrition, Nutricost, NOW Foods, Fairhaven Health, Wholesome Story · read 2026-08-27
    what it says
    “High Potency Vitamin B Complex with Methyl Folate & Methyl B12 … Women, Myo & D-Chiro Inositol, 120 Capsules … Inositol, 500 mg, 100 Veg Capsules … Myo + D-Chiro Inositol, 120 Capsules … Myo & D-Chiro Inositol”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.