{"ok":true,"entry":{"slug":"inositol","kind":"supplement","name":"inositol","aliases":["myo-inositol","D-chiro-inositol","vitamin B8"],"brands_sg":["California Gold Nutrition","Nutricost","NOW Foods","Fairhaven Health","Wholesome Story"],"class":"vitamin-like compound","tags":["womens-health","sleep"],"use_for":"pcos — androgens, insulin resistance and ovulation rates","use_after":"daily","use_duration":null,"take_with":"folic acid · mi+fa did better than other forms","pros":["moderate-quality evidence for testosterone and homa-ir","ovulation rate rr 2.75; live births rr 2.29 vs placebo","fewer gi adverse events than metformin in the review"],"cons":["no high-quality evidence; 41% of items rated very low","vs metformin, most outcomes showed no difference","sleep data: one 10-week trial in 56 pregnant women"],"dose_note":"the 2026 umbrella review suggests a daily intake of 2–4 g for women with pcos, preferably combined with folic acid; the sleep trial it cites used 2000 mg of myo-inositol an hour before bed for 10 weeks in pregnancy; the body itself makes roughly 4 g a day, mainly in the kidneys","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["d-chiro-inositol on its own — the review advises caution","insulin sensitivity shifts — a doctor should know first","pregnancy — the sleep evidence is a single small trial","not listed in hsa annex a or b (oct 2025) — not a clearance"],"clashes":[],"sources":[{"id":"inos_umb_outcomes","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Effects of inositol in women with polycystic ovary syndrome: an umbrella review of meta-analyses from randomized controlled trials (Front Endocrinol 2026) — pooled outcomes","quote":"it reduced serum luteinizing hormone … total testosterone (TT), free testosterone … improved sex hormone-binding globulin … HOMA-IR … and reproductive outcomes (live births: Risk Ratio [RR] 2.29 … ovulation rate: RR 2.75)","accessed":"2026-08-27"},{"id":"inos_umb_grade","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — evidence quality","quote":"GRADE assessment of 85 evidence items revealed no high-quality evidence; 18.9% were moderate, 40% low, and 41.1% very low quality","accessed":"2026-08-27"},{"id":"inos_umb_conclusion","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — conclusion","quote":"Supported by moderate-quality evidence for effects on TT, FT, SHBG, HOMA-IR, and pregnancy/ovulation rates, it is a promising therapy … outcomes based on low-quality evidence require cautious interpretation","accessed":"2026-08-27"},{"id":"inos_umb_subtype","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — inositol subtypes","quote":"Cross-subgroup analysis of inositol subtypes indicated MI/MI+FA was superior for metabolic and reproductive outcomes, while D-chiro-inositol monotherapy should be used with caution in clinical practice","accessed":"2026-08-27"},{"id":"inos_umb_dose","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — clinical implications (recommended dosage)","quote":"Based on effective doses reported in the majority of included studies, a daily intake of 2-4g of inositol is suggested for women with PCOS, preferably in combination with folic acid (e.g., MI+FA)","accessed":"2026-08-27"},{"id":"inos_umb_safety","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — safety versus metformin","quote":"compared to MET, which commonly causes gastrointestinal adverse reactions, inositol demonstrates a lower risk of adverse events","accessed":"2026-08-27"},{"id":"inos_umb_mech","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — mechanism and endogenous synthesis","quote":"MI enhances insulin sensitivity, aiding PCOS patients in restoring ovulation and hormonal balance","accessed":"2026-08-27"},{"id":"inos_umb_endogenous","url":"https://europepmc.org/article/PMC/PMC12932251","label":"Front Endocrinol 2026 umbrella review — what inositol is","quote":"Inositol, a naturally occurring carbohydrate of the sugar alcohol class, contributes to glucose metabolism … the human body can synthesize approximately 4 grams daily through endogenous pathways (primarily in the kidneys)","accessed":"2026-08-27"},{"id":"nr_inositol_trial","url":"https://europepmc.org/article/PMC/PMC13075487","label":"Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review (Nutrition Reviews 2026) — myoinositol section","quote":"received either 2000 mg of myoinositol … or placebo … every night, 1 hour prior to bedtime, for 10 weeks. Postintervention, subjective sleep quality, sleep duration, and sleep efficiency were significantly increased … no objective sleep assessment was conducted","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/inositol","label":"iHerb Singapore — Inositol category (default order); first 5 distinct brands in page order: California Gold Nutrition, Nutricost, NOW Foods, Fairhaven Health, Wholesome Story","quote":"High Potency Vitamin B Complex with Methyl Folate & Methyl B12 … Women, Myo & D-Chiro Inositol, 120 Capsules … Inositol, 500 mg, 100 Veg Capsules … Myo + D-Chiro Inositol, 120 Capsules … Myo & D-Chiro Inositol","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}