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Hydralazine

Medication vasodilator antihypertensive heart & blood pressure
Aka: Apresoline
Brands seen in Singapore: Apo-Hydralazine, Hydralazine
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
US label: essential hypertension, alone or as an adjunct
When to take
HealthHub: long-term use · not stopped without checking
Take with
HealthHub: with or without food
Pros & cons
Pros
  • HealthHub: it works by relaxing blood vessels
  • HealthHub: it may be taken with or without food
  • SG register: 10, 25 and 50 mg tablets registered in SG
Cons
  • HealthHub: fast heartbeat, flushing, headache common
  • US label: may produce a lupus-like picture in a few
  • US label: contraindicated in coronary artery disease
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026 · read 2026-08-27
    what it says
    “APO-HYDRALAZINE TABLET 25 mg SIN00210P, 50 mg SIN01148P, 10 mg SIN00211P (Pharmaforte); HYDRALAZINE TABLETS 10 mg SIN01086P and 50 mg SIN01089P (Beacons) — HYDRALAZINE HCl, ATC C02DB02, all 5 rows Prescription Only”
  2. MOH National Drug Formulary (Singapore) — APO-HYDRALAZINE TABLET 25 MG [SIN00210P], product information (no dosing section published) · read 2026-08-27
    what it says
    “HYDRALAZINE HCL - 25 MG … Registration Number SIN00210P … Licence Holder PHARMAFORTE SINGAPORE PTE LTD … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C02DB02”
  3. MOH National Drug Formulary (Singapore) — HYDRALAZINE TABLETS 10 MG [SIN01086P], product information (no dosing section published) · read 2026-08-27
    what it says
    “HYDRALAZINE HCL - 10 MG … Registration Number SIN01086P … Licence Holder BEACONS PHARMACEUTICALS PTE. LTD. … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C02DB02”
  4. HealthHub (MOH Singapore) — Hydralazine, medication information leaflet (reviewed 25 February 2026) · read 2026-08-27
    what it says
    “Hydralazine is used to treat high blood pressure. This medication works by relaxing blood vessels … You may take this medication with or without food … Do not stop taking your medication without checking with your healthcare professional”
  5. HealthHub (MOH Singapore) — Hydralazine, common and rare side effects · read 2026-08-27
    what it says
    “Dizziness and light-headedness … Headache … Fast heartbeat and palpitations … Flushing (reddening of the skin) … Nausea … Rarely this medication may cause: Drug-induced lupus … Liver problems”
  6. HealthHub (MOH Singapore) — Hydralazine, precautions · read 2026-08-27
    what it says
    “Inform your healthcare professional if: You are allergic to this medication … You are pregnant, planning to become pregnant, or breastfeeding. You are taking any other medications, including supplements, traditional medications and herbal remedies”
  7. HealthHub (MOH Singapore) — Hydralazine, food and medication to avoid · read 2026-08-27
    what it says
    “Avoid drinking alcohol as it may affect you more than usual and increase the side effects of the medication”
  8. Hydralazine hydrochloride tablets — US prescribing information, openFDA drug label record, Indications and Usage · read 2026-08-27
    what it says
    “Essential hypertension, alone or as an adjunct”
  9. Hydralazine hydrochloride tablets (brand name Apresoline in older labelling) — US prescribing information, Dosage and Administration · read 2026-08-27
    what it says
    “Start with 10 mg four times daily for the first 2 to 4 days, increase to 25 mg four times daily for the balance of the first week … increase dosage to 50 mg four times daily”
  10. Hydralazine hydrochloride tablets — US prescribing information, Dosage and Administration: the ceiling and its cost · read 2026-08-27
    what it says
    “The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses … In a few resistant patients, up to 300 mg … daily may be required”
  11. Hydralazine hydrochloride tablets — US prescribing information, Warnings · read 2026-08-27
    what it says
    “In a few patients hydrALAZINE may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis … Symptoms and signs usually regress when the drug is discontinued but residua have been detected many years later”
  12. Hydralazine hydrochloride tablets — US prescribing information, Contraindications · read 2026-08-27
    what it says
    “Hypersensitivity to hydrALAZINE; coronary artery disease; mitral valvular rheumatic heart disease”
  13. Hydralazine hydrochloride tablets — US prescribing information, Precautions: General · read 2026-08-27
    what it says
    “The drug may reduce the pressor responses to epinephrine … hydrALAZINE should be used with caution in patients with advanced renal damage … Peripheral neuritis, evidenced by paresthesia, numbness, and tingling, has been observed”
  14. Hydralazine hydrochloride tablets — US prescribing information, Precautions: Drug and Drug/Food Interactions · read 2026-08-27
    what it says
    “MAO inhibitors should be used with caution in patients receiving hydrALAZINE … Profound hypotensive episodes may occur when diazoxide injection and hydrALAZINE are used concomitantly … Administration of hydrALAZINE with food results in higher plasma levels”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.