{"ok":true,"entry":{"slug":"hydralazine","kind":"medication","name":"hydralazine","aliases":["Apresoline"],"brands_sg":["Apo-Hydralazine","Hydralazine"],"class":"vasodilator antihypertensive","tags":["heart-bp"],"use_for":"us label: essential hypertension, alone or as an adjunct","use_after":"healthhub: long-term use · not stopped without checking","use_duration":null,"take_with":"healthhub: with or without food","pros":["healthhub: it works by relaxing blood vessels","healthhub: it may be taken with or without food","sg register: 10, 25 and 50 mg tablets registered in sg"],"cons":["healthhub: fast heartbeat, flushing, headache common","us label: may produce a lupus-like picture in a few","us label: contraindicated in coronary artery disease"],"dose_note":"no singapore label text could be read for this molecule — neither ndf page (apo-hydralazine sin00210p, beacons hydralazine sin01086p) carries an indication, dosing or contraindication section, so the ceiling below is the us label's, not an hsa-approved sg figure. the us hydralazine hydrochloride tablet label states \"start with 10 mg four times daily for the first 2 to 4 days, increase to 25 mg four times daily for the balance of the first week. for the second and subsequent weeks, increase dosage to 50 mg four times daily\", and for the ceiling: \"in a few resistant patients, up to 300 mg of hydralazine hydrochloride tablets daily may be required for a significant antihypertensive effect\". the same page attaches a cost to that ceiling — \"the incidence of toxic reactions, particularly the l.e. cell syndrome, is high in the group of patients receiving large doses\". as directed on the label or by your doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["coronary artery disease — a us label contraindication","mitral valvular rheumatic heart disease — a us label contraindication","pregnant, planning pregnancy or breastfeeding — healthhub asks that this be declared before starting","advanced kidney damage — us label asks for caution"],"clashes":[{"src":["fda_hydral_di"],"note":"us label: mao inhibitors should be used with caution in patients receiving hydralazine","with":"mao inhibitors"},{"src":["fda_hydral_di"],"note":"us label: profound hypotensive episodes may occur when diazoxide injection and hydralazine are used together","with":"potent parenteral antihypertensives such as diazoxide"},{"src":["healthhub_hydral_food"],"food":true,"note":"healthhub: it may affect you more than usual and increase the side effects","with":"alcohol"},{"src":["fda_hydral_prec"],"note":"us label: the drug may reduce the pressor responses to epinephrine","with":"adrenaline (epinephrine)"},{"src":["fda_hydral_di","healthhub_hydralazine"],"food":true,"note":"us label: administration with food results in higher plasma levels — healthhub still says with or without food","with":"food"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026","quote":"APO-HYDRALAZINE TABLET 25 mg SIN00210P, 50 mg SIN01148P, 10 mg SIN00211P (Pharmaforte); HYDRALAZINE TABLETS 10 mg SIN01086P and 50 mg SIN01089P (Beacons) — HYDRALAZINE HCl, ATC C02DB02, all 5 rows Prescription Only","accessed":"2026-08-27"},{"id":"ndf_hydral_apo","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00210p/","label":"MOH National Drug Formulary (Singapore) — APO-HYDRALAZINE TABLET 25 MG [SIN00210P], product information (no dosing section published)","quote":"HYDRALAZINE HCL - 25 MG … Registration Number SIN00210P … Licence Holder PHARMAFORTE SINGAPORE PTE LTD … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C02DB02","accessed":"2026-08-27"},{"id":"ndf_hydral_beacons","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin01086p/","label":"MOH National Drug Formulary (Singapore) — HYDRALAZINE TABLETS 10 MG [SIN01086P], product information (no dosing section published)","quote":"HYDRALAZINE HCL - 10 MG … Registration Number SIN01086P … Licence Holder BEACONS PHARMACEUTICALS PTE. LTD. … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code C02DB02","accessed":"2026-08-27"},{"id":"healthhub_hydralazine","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hydralazine","label":"HealthHub (MOH Singapore) — Hydralazine, medication information leaflet (reviewed 25 February 2026)","quote":"Hydralazine is used to treat high blood pressure. This medication works by relaxing blood vessels … You may take this medication with or without food … Do not stop taking your medication without checking with your healthcare professional","accessed":"2026-08-27"},{"id":"healthhub_hydral_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hydralazine","label":"HealthHub (MOH Singapore) — Hydralazine, common and rare side effects","quote":"Dizziness and light-headedness … Headache … Fast heartbeat and palpitations … Flushing (reddening of the skin) … Nausea … Rarely this medication may cause: Drug-induced lupus … Liver problems","accessed":"2026-08-27"},{"id":"healthhub_hydral_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hydralazine","label":"HealthHub (MOH Singapore) — Hydralazine, precautions","quote":"Inform your healthcare professional if: You are allergic to this medication … You are pregnant, planning to become pregnant, or breastfeeding. You are taking any other medications, including supplements, traditional medications and herbal remedies","accessed":"2026-08-27"},{"id":"healthhub_hydral_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hydralazine","label":"HealthHub (MOH Singapore) — Hydralazine, food and medication to avoid","quote":"Avoid drinking alcohol as it may affect you more than usual and increase the side effects of the medication","accessed":"2026-08-27"},{"id":"fda_hydral_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets — US prescribing information, openFDA drug label record, Indications and Usage","quote":"Essential hypertension, alone or as an adjunct","accessed":"2026-08-27"},{"id":"fda_hydral_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets (brand name Apresoline in older labelling) — US prescribing information, Dosage and Administration","quote":"Start with 10 mg four times daily for the first 2 to 4 days, increase to 25 mg four times daily for the balance of the first week … increase dosage to 50 mg four times daily","accessed":"2026-08-27"},{"id":"fda_hydral_max","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets — US prescribing information, Dosage and Administration: the ceiling and its cost","quote":"The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses … In a few resistant patients, up to 300 mg … daily may be required","accessed":"2026-08-27"},{"id":"fda_hydral_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets — US prescribing information, Warnings","quote":"In a few patients hydrALAZINE may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis … Symptoms and signs usually regress when the drug is discontinued but residua have been detected many years later","accessed":"2026-08-27"},{"id":"fda_hydral_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets — US prescribing information, Contraindications","quote":"Hypersensitivity to hydrALAZINE; coronary artery disease; mitral valvular rheumatic heart disease","accessed":"2026-08-27"},{"id":"fda_hydral_prec","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets — US prescribing information, Precautions: General","quote":"The drug may reduce the pressor responses to epinephrine … hydrALAZINE should be used with caution in patients with advanced renal damage … Peripheral neuritis, evidenced by paresthesia, numbness, and tingling, has been observed","accessed":"2026-08-27"},{"id":"fda_hydral_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22hydralazine+hydrochloride%22&limit=2","label":"Hydralazine hydrochloride tablets — US prescribing information, Precautions: Drug and Drug/Food Interactions","quote":"MAO inhibitors should be used with caution in patients receiving hydrALAZINE … Profound hypotensive episodes may occur when diazoxide injection and hydrALAZINE are used concomitantly … Administration of hydrALAZINE with food results in higher plasma levels","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}