← All supplements

Hyaluronic acid

Supplement glycosaminoglycan skin & hairbone & joint
Aka: sodium hyaluronate, HA
Brands seen in Singapore: California Gold Nutrition, NOW Foods, NeoCell, k2o by Sprinter, Vitamatic
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Joint trials mostly positive · skin photoaging: no effect
When to take
Daily
Take with
Often sold blended with collagen or chondroitin
Studied for
Joint trials ran 4 weeks to 12 months
Pros & cons
Pros
  • 11 oral trials, 597 people · 9 of 11 improved
  • Side effects rare and mild across those 11 trials
  • No adverse events in 3 of 4 skin trials
Cons
  • Skin meta-analysis: no benefit vs placebo
  • Many joint trials used blends, not ha alone
  • Skin trials were 4–12 weeks and highly heterogeneous
Sources
  1. Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review (de Carvalho & Davidson, Mediterr J Rheumatol 2024) · read 2026-08-27
    what it says
    “Eleven articles were found with 597 patients … The oral HA dosage varied from 30 mg to 300 mg/day … 9/11 articles observed improvement … in the following parameters: VAS pain, WOMAC, joint function, SF-36, Lequesne index, and stiffness”
  2. de Carvalho & Davidson, Mediterr J Rheumatol 2024 — participant ages, follow-up and side effects · read 2026-08-27
    what it says
    “Age varied from 40 to 70 years old … Follow-up ranged from 4 weeks to 12 months … Adverse effects were rare and mild … All mild (dyspepsia, flatulence and puritus) … Gastric discomfort (2), reflux esophagitis (1)”
  3. de Carvalho & Davidson, Mediterr J Rheumatol 2024 — Table 1 product compositions · read 2026-08-27
    what it says
    “Ialoral®: 120 mg HA, 240 mg chondroitin sulphate, 300 mg bioactive oligopeptides of natural hydrolysed keratin, manganese and piperine … Syalox® 300 Plus: 300 mg of HA and 100 mg of B. serrata”
  4. Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of RCTs (Front Med 2025) · read 2026-08-27
    what it says
    “hyaluronic acid, lycopene, and carotenoids did not show any significant benefits in improving skin photoaging or MED/R2 … no significant statistically discernable distinction between the group that received hyaluronic acid and the group that received a placebo”
  5. Front Med 2025 — section 3.9, hyaluronan subgroup · read 2026-08-27
    what it says
    “Four studies … 178 participants explored the use of hyaluronic acid … doses ranging from 120 to 200 mg … a range of 4–12 weeks … (SMD = 1.88;95% CI: –1.06–4.83, p = 0.21)”
  6. Front Med 2025 — safety of the oral supplements reviewed · read 2026-08-27
    what it says
    “during the study period (typically ≤ 24 weeks), all orally administered dietary supplements were found to be safe … Three of the four studies … explicitly did not have adverse events”
  7. Front Med 2025 — study population and exclusion criteria · read 2026-08-27
    what it says
    “healthy adults, spanning a wide range of ages from 18 to 75 years … We excluded individuals who were pregnant or breastfeeding, and those diagnosed with metabolic, cardiovascular, or hepatic disorders”
  8. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [hyaluronic acid / sodium hyaluronate not listed in Annex A or B]”
  9. HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev 020 (Jan 2026), Table 5: Minerals Limits · read 2026-08-27
    what it says
    “Table 5: Minerals Limits … Nutrient Maximum Daily Limit Boron 6.4 mg Calcium 1200 mg Chromium 0.5 mg Copper 2 mg Iodine 0.15 mg Iron 15 mg* Magnesium 350 mg Manganese 3.5 mg … Selenium 0.2 mg Zinc 15 mg”
  10. iHerb Singapore — Hyaluronic Acid category page, Hair, Skin & Nails (default order, 89 results) · read 2026-08-27
    what it says
    “California Gold Nutrition, CollagenUP®, … Hyaluronic Acid and Vitamin C … NOW Foods, Hyaluronic Acid With L-Proline … NeoCell, Marine Collagen Peptides + Hyaluronic Acid … k2o by Sprinter, Advanced Skin Hydration Mix … Vitamatic, Hyaluronic Acid, High Potency”
Report a correction View as JSON

Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.