{"ok":true,"entry":{"slug":"hyaluronic-acid","kind":"supplement","name":"hyaluronic acid","aliases":["sodium hyaluronate","HA"],"brands_sg":["California Gold Nutrition","NOW Foods","NeoCell","k2o by Sprinter","Vitamatic"],"class":"glycosaminoglycan","tags":["skin-hair","bone-joint"],"use_for":"joint trials mostly positive · skin photoaging: no effect","use_after":"daily","use_duration":"joint trials ran 4 weeks to 12 months","take_with":"often sold blended with collagen or chondroitin","pros":["11 oral trials, 597 people · 9 of 11 improved","side effects rare and mild across those 11 trials","no adverse events in 3 of 4 skin trials"],"cons":["skin meta-analysis: no benefit vs placebo","many joint trials used blends, not ha alone","skin trials were 4–12 weeks and highly heterogeneous"],"dose_note":"joint trials use 30–300 mg a day of oral hyaluronic acid for 4 weeks to 12 months, frequently inside blends with chondroitin, keratin peptides or boswellia; skin photoaging trials use 120–200 mg a day for 4–12 weeks and did not beat placebo on elasticity","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["reflux or dyspepsia — mild gut effects were reported","pregnant or breastfeeding — excluded from these trials","under 18 — joint trial ages ran 40 to 70"],"clashes":[],"sources":[{"id":"decarvalho2024","url":"https://europepmc.org/article/PMC/PMC11778613","label":"Oral Hyaluronic Acid in Osteoarthritis and Low Back Pain: A Systematic Review (de Carvalho & Davidson, Mediterr J Rheumatol 2024)","quote":"Eleven articles were found with 597 patients … The oral HA dosage varied from 30 mg to 300 mg/day … 9/11 articles observed improvement … in the following parameters: VAS pain, WOMAC, joint function, SF-36, Lequesne index, and stiffness","accessed":"2026-08-27"},{"id":"decarvalho2024_ae","url":"https://europepmc.org/article/PMC/PMC11778613","label":"de Carvalho & Davidson, Mediterr J Rheumatol 2024 — participant ages, follow-up and side effects","quote":"Age varied from 40 to 70 years old … Follow-up ranged from 4 weeks to 12 months … Adverse effects were rare and mild … All mild (dyspepsia, flatulence and puritus) … Gastric discomfort (2), reflux esophagitis (1)","accessed":"2026-08-27"},{"id":"decarvalho2024_combo","url":"https://europepmc.org/article/PMC/PMC11778613","label":"de Carvalho & Davidson, Mediterr J Rheumatol 2024 — Table 1 product compositions","quote":"Ialoral®: 120 mg HA, 240 mg chondroitin sulphate, 300 mg bioactive oligopeptides of natural hydrolysed keratin, manganese and piperine … Syalox® 300 Plus: 300 mg of HA and 100 mg of B. serrata","accessed":"2026-08-27"},{"id":"li2025_photoaging","url":"https://europepmc.org/article/PMC/PMC12318760","label":"Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of RCTs (Front Med 2025)","quote":"hyaluronic acid, lycopene, and carotenoids did not show any significant benefits in improving skin photoaging or MED/R2 … no significant statistically discernable distinction between the group that received hyaluronic acid and the group that received a placebo","accessed":"2026-08-27"},{"id":"li2025_ha_detail","url":"https://europepmc.org/article/PMC/PMC12318760","label":"Front Med 2025 — section 3.9, hyaluronan subgroup","quote":"Four studies … 178 participants explored the use of hyaluronic acid … doses ranging from 120 to 200 mg … a range of 4–12 weeks … (SMD = 1.88;95% CI: –1.06–4.83, p = 0.21)","accessed":"2026-08-27"},{"id":"li2025_safety","url":"https://europepmc.org/article/PMC/PMC12318760","label":"Front Med 2025 — safety of the oral supplements reviewed","quote":"during the study period (typically ≤ 24 weeks), all orally administered dietary supplements were found to be safe … Three of the four studies … explicitly did not have adverse events","accessed":"2026-08-27"},{"id":"li2025_population","url":"https://europepmc.org/article/PMC/PMC12318760","label":"Front Med 2025 — study population and exclusion criteria","quote":"healthy adults, spanning a wide range of ages from 18 to 75 years … We excluded individuals who were pregnant or breastfeeding, and those diagnosed with metabolic, cardiovascular, or hepatic disorders","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [hyaluronic acid / sodium hyaluronate not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"hsa_hs_2026","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev 020 (Jan 2026), Table 5: Minerals Limits","quote":"Table 5: Minerals Limits … Nutrient Maximum Daily Limit Boron 6.4 mg Calcium 1200 mg Chromium 0.5 mg Copper 2 mg Iodine 0.15 mg Iron 15 mg* Magnesium 350 mg Manganese 3.5 mg … Selenium 0.2 mg Zinc 15 mg","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/hyaluronic-acid","label":"iHerb Singapore — Hyaluronic Acid category page, Hair, Skin & Nails (default order, 89 results)","quote":"California Gold Nutrition, CollagenUP®, … Hyaluronic Acid and Vitamin C … NOW Foods, Hyaluronic Acid With L-Proline … NeoCell, Marine Collagen Peptides + Hyaluronic Acid … k2o by Sprinter, Advanced Skin Hydration Mix … Vitamatic, Hyaluronic Acid, High Potency","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}