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Green-lipped mussel

Supplement marine extract bone & joint
Aka: Perna canaliculus, Lyprinol
Brands seen in Singapore: Swanson Vitamins, Nature's Life, Vitamatic, Advanced Orthomolecular Research AOR, DaVinci Laboratories
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Knee joint pain · small trials, low-quality evidence
Studied for
The recent RCT ran 12 weeks of daily use
Pros & cons
Pros
  • A 12-week RCT's per-protocol womac score improved
  • Mussel oil was the one marine oil with an effect
Cons
  • The SAMe RCT's itt analysis missed significance
  • The pooled marine-oil evidence was low quality
  • HSA's numeric limits cover vitamins/minerals only
Sources
  1. Efficacy and safety of green-lipped mussel powder supplementation in adults with knee osteoarthritis: a randomized, double-blind, placebo-controlled trial (Kim et al., BMC Complement Med Ther 2026) · read 2026-08-27
    what it says
    “GLMP (1,000 mg/day) or placebo for 12 weeks … In the PP analysis, GLMP resulted in greater improvement in WOMAC total score … In the ITT analysis … WOMAC total score showed a non-significant trend favoring GLMP (p = 0.061)”
  2. Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials (Senftleber et al., Nutrients 2017) · read 2026-08-27
    what it says
    “The analysis showed a significant relationship between pain and type of marine oil … where only the effect of mussel oil was statistically significant on its own, having a beneficial effect … evidence … was overall of low quality”
  3. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.”
  4. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025) · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  5. iHerb Singapore — Green Lipped Mussel category page · read 2026-08-27
    what it says
    “Green Lipped Mussel: New Zealand 500 mg Capsules | iHerb”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.