{"ok":true,"entry":{"slug":"green-lipped-mussel","kind":"supplement","name":"green-lipped mussel","aliases":["Perna canaliculus","Lyprinol"],"brands_sg":["Swanson Vitamins","Nature's Life","Vitamatic","Advanced Orthomolecular Research AOR","DaVinci Laboratories"],"class":"marine extract","tags":["bone-joint"],"use_for":"knee joint pain · small trials, low-quality evidence","use_after":null,"use_duration":"the recent rct ran 12 weeks of daily use","take_with":null,"pros":["a 12-week rct's per-protocol womac score improved","mussel oil was the one marine oil with an effect"],"cons":["the same rct's itt analysis missed significance","the pooled marine-oil evidence was low quality","hsa's numeric limits cover vitamins/minerals only"],"dose_note":"one 12-week rct used 1,000 mg a day of green-lipped mussel powder","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["shellfish allergy — the supplement is mussel powder","not on hsa's prohibited/restricted lists — which are not exhaustive"],"clashes":[],"sources":[{"id":"kim2026","url":"https://europepmc.org/article/MED/42464085","label":"Efficacy and safety of green-lipped mussel powder supplementation in adults with knee osteoarthritis: a randomized, double-blind, placebo-controlled trial (Kim et al., BMC Complement Med Ther 2026)","quote":"GLMP (1,000 mg/day) or placebo for 12 weeks … In the PP analysis, GLMP resulted in greater improvement in WOMAC total score … In the ITT analysis … WOMAC total score showed a non-significant trend favoring GLMP (p = 0.061)","accessed":"2026-08-27"},{"id":"senftleber2017","url":"https://europepmc.org/article/PMC/PMC5295086","label":"Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials (Senftleber et al., Nutrients 2017)","quote":"The analysis showed a significant relationship between pain and type of marine oil … where only the effect of mussel oil was statistically significant on its own, having a beneficial effect … evidence … was overall of low quality","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/green-lipped-mussel","label":"iHerb Singapore — Green Lipped Mussel category page","quote":"Green Lipped Mussel: New Zealand 500 mg Capsules | iHerb","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}