← All supplements

Grape seed extract

Supplement botanical extract heart & metabolicskin & hair
Aka: OPC, proanthocyanidins, Vitis vinifera
Brands seen in Singapore: California Gold Nutrition, NOW Foods, Nutricost, Vitacost, Terry Naturally
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
LDL and triglycerides; diastolic bp in a 2022 review
Pros & cons
Pros
  • 2020 review of 11 trials: LDL and triglycerides moved
  • 2022 review of 19 trials: diastolic bp came down
  • Generally well tolerated taken orally or topically
Cons
  • Not definite — small trials, product composition varied
  • No shift in systolic bp, total or HDL cholesterol
  • Skin wound-healing research in people is very limited
Sources
  1. NCCIH — Grape Seed Extract (Last Updated: February 2025), Background · read 2026-08-27
    what it says
    “Grape seed extract, which is made from the seeds of wine grapes, is promoted as a dietary supplement for various purposes, including reducing blood cholesterol and blood pressure”
  2. NCCIH — Grape Seed Extract: active constituents · read 2026-08-27
    what it says
    “Grape seed extract contains proanthocyanidins, which have a variety of effects that might be beneficial in managing health conditions.”
  3. NCCIH — Grape Seed Extract: 2020 review of 11 studies (536 participants) · read 2026-08-27
    what it says
    “A 2020 review of 11 studies (536 participants) showed that grape seed extract may have desirable effects on levels of low-density lipoprotein (LDL) cholesterol and triglycerides but not on total cholesterol and high-density lipoprotein (HDL) cholesterol levels.”
  4. NCCIH — Grape Seed Extract: 2022 review of 19 studies (1,080 participants) · read 2026-08-27
    what it says
    “A 2022 review of 19 studies (1,080 participants) showed that grape seed extract reduced diastolic blood pressure (the lower number in a blood pressure reading) but not systolic blood pressure (the higher number).”
  5. NCCIH — Grape Seed Extract: how firm those conclusions are · read 2026-08-27
    what it says
    “These conclusions should not be considered definite because the studies were small, and the composition of the products varied from study to study.”
  6. NCCIH — Grape Seed Extract: wound healing / skin · read 2026-08-27
    what it says
    “application of grape seed extract to the skin may promote wound healing, but only a very small amount of research has been done on this topic in people”
  7. NCCIH — Grape Seed Extract: tolerability · read 2026-08-27
    what it says
    “Grape seed extract is generally well tolerated when taken orally or used topically.”
  8. NCCIH — Grape Seed Extract: medicines · read 2026-08-27
    what it says
    “If you take any type of medicine, talk with your health care provider before using grape seed extract or other herbal products; some herbs and medicines interact in harmful ways.”
  9. NCCIH — Grape Seed Extract: pregnancy and breastfeeding · read 2026-08-27
    what it says
    “Little is known about whether it’s safe to use grape seed extract during pregnancy or while breastfeeding.”
  10. HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025), Annex A/B — searched, no row for this ingredient · read 2026-08-27
    what it says
    “The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.”
  11. iHerb Singapore — Grape Seed Extract category (default order, 1 - 48 of 53 results) · read 2026-08-27
    what it says
    “California Gold Nutrition, French Grape Seed Extract, Vitaflavan®, 100 mg … NOW Foods, Grape Seed Extract, 500 mg … Nutricost, Grape Seed Extract, 400 mg per Capsule … Vitacost, Grape Seed Extract, 200 mg … Terry Naturally, Clinical OPC®”
Report a correction View as JSON

Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.