{"ok":true,"entry":{"slug":"grape-seed-extract","kind":"supplement","name":"grape seed extract","aliases":["OPC","proanthocyanidins","Vitis vinifera"],"brands_sg":["California Gold Nutrition","NOW Foods","Nutricost","Vitacost","Terry Naturally"],"class":"botanical extract","tags":["heart","skin-hair"],"use_for":"ldl and triglycerides; diastolic bp in a 2022 review","use_after":null,"use_duration":null,"take_with":null,"pros":["2020 review of 11 trials: ldl and triglycerides moved","2022 review of 19 trials: diastolic bp came down","generally well tolerated taken orally or topically"],"cons":["not definite — small trials, product composition varied","no shift in systolic bp, total or hdl cholesterol","skin wound-healing research in people is very limited"],"dose_note":"nccih quotes no dose and says the composition of the products varied from study to study; the sg listings' 100–500 mg a capsule are label strengths, not studied doses","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["on any medicine — nccih says to talk with your health care provider first","pregnancy or breastfeeding — little is known about safety","not listed in hsa's annex a/b — not the same as cleared"],"clashes":[],"sources":[{"id":"nccih_gse_promoted","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract (Last Updated: February 2025), Background","quote":"Grape seed extract, which is made from the seeds of wine grapes, is promoted as a dietary supplement for various purposes, including reducing blood cholesterol and blood pressure","accessed":"2026-08-27"},{"id":"nccih_gse_opc","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: active constituents","quote":"Grape seed extract contains proanthocyanidins, which have a variety of effects that might be beneficial in managing health conditions.","accessed":"2026-08-27"},{"id":"nccih_gse_lipids","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: 2020 review of 11 studies (536 participants)","quote":"A 2020 review of 11 studies (536 participants) showed that grape seed extract may have desirable effects on levels of low-density lipoprotein (LDL) cholesterol and triglycerides but not on total cholesterol and high-density lipoprotein (HDL) cholesterol levels.","accessed":"2026-08-27"},{"id":"nccih_gse_bp","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: 2022 review of 19 studies (1,080 participants)","quote":"A 2022 review of 19 studies (1,080 participants) showed that grape seed extract reduced diastolic blood pressure (the lower number in a blood pressure reading) but not systolic blood pressure (the higher number).","accessed":"2026-08-27"},{"id":"nccih_gse_caveat","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: how firm those conclusions are","quote":"These conclusions should not be considered definite because the studies were small, and the composition of the products varied from study to study.","accessed":"2026-08-27"},{"id":"nccih_gse_skin","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: wound healing / skin","quote":"application of grape seed extract to the skin may promote wound healing, but only a very small amount of research has been done on this topic in people","accessed":"2026-08-27"},{"id":"nccih_gse_safety","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: tolerability","quote":"Grape seed extract is generally well tolerated when taken orally or used topically.","accessed":"2026-08-27"},{"id":"nccih_gse_meds","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: medicines","quote":"If you take any type of medicine, talk with your health care provider before using grape seed extract or other herbal products; some herbs and medicines interact in harmful ways.","accessed":"2026-08-27"},{"id":"nccih_gse_preg","url":"https://www.nccih.nih.gov/health/grape-seed-extract","label":"NCCIH — Grape Seed Extract: pregnancy and breastfeeding","quote":"Little is known about whether it’s safe to use grape seed extract during pregnancy or while breastfeeding.","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025), Annex A/B — searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/grape-seed-extract","label":"iHerb Singapore — Grape Seed Extract category (default order, 1 - 48 of 53 results)","quote":"California Gold Nutrition, French Grape Seed Extract, Vitaflavan®, 100 mg … NOW Foods, Grape Seed Extract, 500 mg … Nutricost, Grape Seed Extract, 400 mg per Capsule … Vitacost, Grape Seed Extract, 200 mg … Terry Naturally, Clinical OPC®","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}