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Glimepiride

Medication sulfonylurea diabetes
Aka: Amaryl
Brands seen in Singapore: Amaryl, Dialosa
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
US label: type 2 diabetes, with diet and exercise
When to take
HealthHub: immediately before a meal, meals not delayed
Take with
HealthHub: the first main meal of the day · no alcohol
Pros & cons
Pros
  • HealthHub: helps the pancreas release more insulin
  • US label: one dose a day, with the first meal
  • SG register lists 2 mg and 3 mg tablets
Cons
  • HealthHub: low blood sugar and weight gain are common
  • HealthHub: over-65s have a higher risk of side effects
  • HealthHub: alcohol can cause flushing and nausea
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), glimepiride rows, 27 Aug 2026 · read 2026-08-27
    what it says
    “AMARYL 2.0 TABLETS 2 mg SIN10459P · DIALOSA TABLET 2MG SIN13675P · DIALOSA TABLET 3MG SIN13674P — ATC A10BB12; all 3 glimepiride rows read Forensicclassification "Prescription Only"”
  2. HealthHub (Pharmaceutical Society of Singapore / MOH) — Glimepiride: what is this medication for · read 2026-08-27
    what it says
    “Glimepiride is used in the treatment of diabetes … It helps the pancreas to release more insulin to bring your blood sugar levels down.”
  3. HealthHub — Glimepiride: how should I take or use this medication · read 2026-08-27
    what it says
    “Take the tablet(s) as directed by your doctor immediately before meal(s). Do not miss or delay meals after taking the medication.”
  4. HealthHub — Glimepiride: what precautions should I take · read 2026-08-27
    what it says
    “Have Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency … Are allergic to sulfonamide drugs … Have heart, kidney or liver problems … Are an elderly above 65 years old as you have a higher risk of having side effects”
  5. HealthHub — Glimepiride: common side effects · read 2026-08-27
    what it says
    “The common side effects of Glimepiride include: Low blood sugar (hypoglycemia) … Weight gain … Symptoms of low blood sugar include: Weakness, Dizziness, Hunger, Sweating, Trembling, Blurred vision”
  6. HealthHub — Glimepiride: what food or medication should I avoid · read 2026-08-27
    what it says
    “Avoid taking alcohol with this medication as it may cause symptoms such as flushing, nausea, vomiting, headache, fast heartbeat, fast breathing and giddiness.”
  7. US label for glimepiride tablets (American Health Packaging, effective 2024-11-13) via openFDA drug/label.json, section 2 Dosage and Administration · read 2026-08-27
    what it says
    “Recommended starting dose is 1 or 2 mg once daily … Maximum recommended dose is 8 mg once daily. Administer with breakfast or first meal of the day.”
  8. US label for glimepiride tablets — section 2.1 Recommended Dosing, via openFDA drug/label.json · read 2026-08-27
    what it says
    “Use 1 mg starting dose and titrate slowly in patients at increased risk for hypoglycemia (e.g., elderly, patients with renal impairment).”
  9. US label for glimepiride tablets — section 1 Indications and Usage, via openFDA drug/label.json · read 2026-08-27
    what it says
    “Glimepiride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus … a sulfonylurea … should not be used for the treatment of type 1 diabetes mellitus”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.