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Fisetin

Supplement flavonoid general nutrition
Aka: senolytic flavonol
Brands seen in Singapore: California Gold Nutrition, Life Extension, Neurogan Health, Doctor's Best, Nutricost
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Limited human evidence — trials track inflammation markers
Pros & cons
Pros
  • A 12-week RCT at 200 mg/day lowered IL-6 and TNF-α
  • Not named in HSA's prohibited or restricted annexes
Cons
  • Senolytic claims rest on cell and animal work
  • Human outcome trials are only now starting
  • No RDA, no upper limit, no SG cap set
Sources
  1. 12-weeks fisetin supplementation and interval resistance with aerobic training: a randomized controlled trial (Alipour et al., JISSN 2026) · read 2026-08-27
    what it says
    “44 obese adult males … control-placebo (CP), fisetin (F) (200 mg/day) … IL-6 decreased in T (p = 0.006), TF (p = 0.001), and F (p = 0.013) groups. TNF-α decreased in all intervention groups”
  2. A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study (Ther Adv Med Oncol 2026) · read 2026-08-27
    what it says
    “preclinical studies show that targeting senescent cells with senolytics can reduce inflammation and improve physical function … however, no study to date has evaluated the effects of senolytics on physical function”
  3. HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A · read 2026-08-27
    what it says
    “Annex A: List of substances which are prohibited or restricted for use with … [fisetin does not appear in Annex A or Annex B]”
  4. HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits · read 2026-08-27
    what it says
    “Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names fisetin]”
  5. iHerb Singapore — fisetin category page (default best-selling order) · read 2026-08-27
    what it says
    “California Gold Nutrition · Life Extension · Neurogan Health · Doctor's Best · Nutricost [first distinct brands, default order]”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.