{"ok":true,"entry":{"slug":"fisetin","kind":"supplement","name":"fisetin","aliases":["senolytic flavonol"],"brands_sg":["California Gold Nutrition","Life Extension","Neurogan Health","Doctor's Best","Nutricost"],"class":"flavonoid","tags":["general"],"use_for":"limited human evidence — trials track inflammation markers","use_after":null,"use_duration":null,"take_with":null,"pros":["a 12-week RCT at 200 mg/day lowered IL-6 and TNF-α","not named in HSA's prohibited or restricted annexes"],"cons":["senolytic claims rest on cell and animal work","human outcome trials are only now starting","no RDA, no upper limit, no SG cap set"],"dose_note":"a 12-week randomized trial used 200 mg a day in 44 men with obesity; longer-term senolytic dosing schedules have not been settled in humans","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["no cognitive endpoint in any human trial found","no upper limit set — absence of a cap is not safety"],"clashes":[],"sources":[{"id":"alipour2026","url":"https://europepmc.org/article/PMC/PMC13224698","label":"12-weeks fisetin supplementation and interval resistance with aerobic training: a randomized controlled trial (Alipour et al., JISSN 2026)","quote":"44 obese adult males … control-placebo (CP), fisetin (F) (200 mg/day) … IL-6 decreased in T (p = 0.006), TF (p = 0.001), and F (p = 0.013) groups. TNF-α decreased in all intervention groups","accessed":"2026-08-27"},{"id":"troffi2026","url":"https://europepmc.org/article/PMC/PMC12979913","label":"A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors: the TROFFi study (Ther Adv Med Oncol 2026)","quote":"preclinical studies show that targeting senescent cells with senolytics can reduce inflammation and improve physical function … however, no study to date has evaluated the effects of senolytics on physical function","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A","quote":"Annex A: List of substances which are prohibited or restricted for use with … [fisetin does not appear in Annex A or Annex B]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names fisetin]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/fisetin","label":"iHerb Singapore — fisetin category page (default best-selling order)","quote":"California Gold Nutrition · Life Extension · Neurogan Health · Doctor's Best · Nutricost [first distinct brands, default order]","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}