← All medications

Febuxostat

Medication xanthine oxidase inhibitor other
Aka: Feburic, Uloric
Brands seen in Singapore: Feburic, Febugout
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed to lower uric acid in gout
When to take
HealthHub: with or without food, kept up between flares
Take with
Water · HealthHub: with or without food
Pros & cons
Pros
  • HealthHub: lowers urate and can shrink tophi over time
  • FDA: 40 mg or 80 mg once daily, food does not matter
  • FDA: an option when allopurinol is unsuitable
Cons
  • FDA boxed warning: more cv deaths than allopurinol
  • FDA: fatal and non-fatal liver failure reported
  • HealthHub: gout flares are common when starting
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched) · read 2026-08-27
    what it says
    “Both registered febuxostat products read Forensicclassification 'Prescription Only' — SIN14959P FEBURIC FILM COATED TABLETS 80MG (Astellas) and SIN17054P FEBUGOUT F.C. TABLETS 80MG (ATC M04AA03)”
  2. HealthHub (Pharmaceutical Society of Singapore) — Febuxostat: what is this medication for · read 2026-08-27
    what it says
    “Febuxostat belongs to a class of medicines called xanthine oxidase inhibitor. It is used for reducing uric acid … can also help to shrink the tophi (bumps which contain urate deposits at the joints).”
  3. HealthHub — Febuxostat: how should I take or use this medication · read 2026-08-27
    what it says
    “The tablets can be taken with or without food … Continue to take Febuxostat as prescribed even when you are not experiencing a gout flare or attack.”
  4. HealthHub — Febuxostat: what precautions should I take · read 2026-08-27
    what it says
    “You are pregnant, planning to become pregnant, or breastfeeding … You have heart, kidney, liver or thyroid problems”
  5. HealthHub — Febuxostat: common side effects · read 2026-08-27
    what it says
    “Diarrhoea, Nausea, Headache, Edema … Muscle pain, Joint pain … You may also experience more frequent gout flares when you first start taking Febuxostat.”
  6. HealthHub — Febuxostat: what food or medication should I avoid · read 2026-08-27
    what it says
    “Some medication such as Azathioprine, Mercaptopurine, Pegloticase and Theophylline should not be taken together with Febuxostat as they might increase the chance of you experiencing severe side effects.”
  7. US FDA label for ULORIC (febuxostat tablets), Indications and Usage, via openFDA (effective 2025-12-24) · read 2026-08-27
    what it says
    “indicated for the chronic management of hyperuricemia in adult patients with gout who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable”
  8. US FDA label for ULORIC, section 2.1 Recommended Dosage, via openFDA · read 2026-08-27
    what it says
    “The recommended ULORIC dosage is 40 mg or 80 mg once daily … For patients who do not achieve a serum uric acid less than 6 mg/dL after two weeks, the recommended ULORIC dosage is 80 mg once daily”
  9. US FDA label for ULORIC, section 2.2 Dosage in Renal and Hepatic Impairment, via openFDA · read 2026-08-27
    what it says
    “The recommended dosage of ULORIC is limited to 40 mg once daily in patients with severe renal impairment.”
  10. US FDA label for ULORIC, Boxed Warning, via openFDA · read 2026-08-27
    what it says
    “Gout patients with established cardiovascular (CV) disease treated with ULORIC had a higher rate of CV death compared to those treated with allopurinol in a CV outcomes study.”
  11. US FDA label for ULORIC, section 5 Warnings and Precautions, via openFDA · read 2026-08-27
    what it says
    “Cases of hepatic failure, some fatal, have been reported … Serious skin and hypersensitivity reactions, including Stevens-Johnson Syndrome, drug reaction with eosinophilia and systemic symptoms and toxic epidermal necrolysis have been reported”
  12. US FDA label for ULORIC, section 4 Contraindications, via openFDA · read 2026-08-27
    what it says
    “ULORIC is contraindicated in patients being treated with azathioprine or mercaptopurine.”
  13. US FDA label for ULORIC, section 7 Drug Interactions, via openFDA · read 2026-08-27
    what it says
    “febuxostat altered the metabolism of theophylline (a substrate of XO) in humans … Therefore, use with caution when coadministering ULORIC with theophylline … an increase in exposure of 6-mercaptopurine which may lead to toxicity”
Report a correction View as JSON

Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.