{"ok":true,"entry":{"slug":"febuxostat","kind":"medication","name":"febuxostat","aliases":["Feburic","Uloric"],"brands_sg":["Feburic","Febugout"],"class":"xanthine oxidase inhibitor","tags":["other"],"use_for":"prescribed to lower uric acid in gout","use_after":"healthhub: with or without food, kept up between flares","use_duration":null,"take_with":"water · healthhub: with or without food","pros":["healthhub: lowers urate and can shrink tophi over time","fda: 40 mg or 80 mg once daily, food does not matter","fda: an option when allopurinol is unsuitable"],"cons":["fda boxed warning: more cv deaths than allopurinol","fda: fatal and non-fatal liver failure reported","healthhub: gout flares are common when starting"],"dose_note":"the us fda label for uloric (febuxostat tablets) states 'The recommended ULORIC dosage is 40 mg or 80 mg once daily', with the 80 mg step for people not reaching a serum urate below 6 mg/dl after two weeks — 80 mg once daily is the label maximum — and it is 'limited to 40 mg once daily in patients with severe renal impairment'. both sg products are 80 mg tablets; no 40 mg strength is registered here. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["existing heart disease or stroke — fda boxed warning: cv death risk","liver problems — fda: hepatic failure reported, liver tests taken","heart, kidney or thyroid problems — healthhub: tell your professional","serious rash — fda: stevens-johnson syndrome and ten reported"],"clashes":[{"src":["fda_feb_ci","hh_feb_food"],"note":"fda: contraindicated — febuxostat can raise their levels and cause severe toxicity","with":"azathioprine or mercaptopurine"},{"src":["fda_feb_di","hh_feb_food"],"note":"fda: febuxostat altered theophylline metabolism in humans; caution when used together","with":"theophylline"},{"src":["hh_feb_food"],"note":"healthhub: named among medicines that should not be taken together with febuxostat","with":"pegloticase"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows; cached at /tmp/hsa_all.json and filtered locally, not re-fetched)","quote":"Both registered febuxostat products read Forensicclassification 'Prescription Only' — SIN14959P FEBURIC FILM COATED TABLETS 80MG (Astellas) and SIN17054P FEBUGOUT F.C. TABLETS 80MG (ATC M04AA03)","accessed":"2026-08-27"},{"id":"hh_feb_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/febuxostat","label":"HealthHub (Pharmaceutical Society of Singapore) — Febuxostat: what is this medication for","quote":"Febuxostat belongs to a class of medicines called xanthine oxidase inhibitor. It is used for reducing uric acid … can also help to shrink the tophi (bumps which contain urate deposits at the joints).","accessed":"2026-08-27"},{"id":"hh_feb_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/febuxostat","label":"HealthHub — Febuxostat: how should I take or use this medication","quote":"The tablets can be taken with or without food … Continue to take Febuxostat as prescribed even when you are not experiencing a gout flare or attack.","accessed":"2026-08-27"},{"id":"hh_feb_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/febuxostat","label":"HealthHub — Febuxostat: what precautions should I take","quote":"You are pregnant, planning to become pregnant, or breastfeeding … You have heart, kidney, liver or thyroid problems","accessed":"2026-08-27"},{"id":"hh_feb_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/febuxostat","label":"HealthHub — Febuxostat: common side effects","quote":"Diarrhoea, Nausea, Headache, Edema … Muscle pain, Joint pain … You may also experience more frequent gout flares when you first start taking Febuxostat.","accessed":"2026-08-27"},{"id":"hh_feb_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/febuxostat","label":"HealthHub — Febuxostat: what food or medication should I avoid","quote":"Some medication such as Azathioprine, Mercaptopurine, Pegloticase and Theophylline should not be taken together with Febuxostat as they might increase the chance of you experiencing severe side effects.","accessed":"2026-08-27"},{"id":"fda_feb_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC (febuxostat tablets), Indications and Usage, via openFDA (effective 2025-12-24)","quote":"indicated for the chronic management of hyperuricemia in adult patients with gout who have an inadequate response to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable","accessed":"2026-08-27"},{"id":"fda_feb_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC, section 2.1 Recommended Dosage, via openFDA","quote":"The recommended ULORIC dosage is 40 mg or 80 mg once daily … For patients who do not achieve a serum uric acid less than 6 mg/dL after two weeks, the recommended ULORIC dosage is 80 mg once daily","accessed":"2026-08-27"},{"id":"fda_feb_renal","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC, section 2.2 Dosage in Renal and Hepatic Impairment, via openFDA","quote":"The recommended dosage of ULORIC is limited to 40 mg once daily in patients with severe renal impairment.","accessed":"2026-08-27"},{"id":"fda_feb_boxed","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC, Boxed Warning, via openFDA","quote":"Gout patients with established cardiovascular (CV) disease treated with ULORIC had a higher rate of CV death compared to those treated with allopurinol in a CV outcomes study.","accessed":"2026-08-27"},{"id":"fda_feb_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC, section 5 Warnings and Precautions, via openFDA","quote":"Cases of hepatic failure, some fatal, have been reported … Serious skin and hypersensitivity reactions, including Stevens-Johnson Syndrome, drug reaction with eosinophilia and systemic symptoms and toxic epidermal necrolysis have been reported","accessed":"2026-08-27"},{"id":"fda_feb_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC, section 4 Contraindications, via openFDA","quote":"ULORIC is contraindicated in patients being treated with azathioprine or mercaptopurine.","accessed":"2026-08-27"},{"id":"fda_feb_di","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ULORIC%22&limit=1","label":"US FDA label for ULORIC, section 7 Drug Interactions, via openFDA","quote":"febuxostat altered the metabolism of theophylline (a substrate of XO) in humans … Therefore, use with caution when coadministering ULORIC with theophylline … an increase in exposure of 6-mercaptopurine which may lead to toxicity","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}