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Ezetimibe

Medication cholesterol absorption inhibitor heart & blood pressure
Aka: Ezetrol
Brands seen in Singapore: Ezetrol, Lipez, Ezzicad, Ezoleta, Alvotrol
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for high cholesterol — a doctor decides
When to take
FDA label: 10 mg once daily, with or without food
Take with
Water · FDA: 2 h before or 4 h after a bile acid binder
Pros & cons
Pros
  • HealthHub: may reduce heart attack and stroke risk
  • FDA label: one 10 mg dose, no titration steps
  • HealthHub: with or without food
Cons
  • HealthHub: diarrhoea, stomach pain, tiredness
  • HealthHub: very rarely muscle or liver problems
  • NHS: little information on herbal supplements
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 31 ezetimibe-containing products carry Forensicclassification 'Prescription Only'; 8 are single-ingredient (ATC C10AX09), every one a 10 mg tablet — SIN12375P EZETROL · SIN15740P LIPEZ · SIN16429P EZZICAD · SIN16422P EZOLETA · SIN15245P ALVOTROL.”
  2. NHS Medicines A-Z — Ezetimibe (index page) · read 2026-08-27
    what it says
    “Ezetimibe: a medicine used to treat high blood cholesterol … Brand name: Ezetrol. Find out how ezetimibe treats high blood cholesterol and how to take it.”
  3. NHS Medicines A-Z — Taking ezetimibe with other medicines and herbal supplements · read 2026-08-27
    what it says
    “ciclosporin, a medicine used to treat psoriasis or after an organ transplant; medicines used to prevent blood clots, such as warfarin; other medicines used for lowering cholesterol (this does not include statins), such as colestyramine or bezafibrate”
  4. NHS Medicines A-Z — Mixing ezetimibe with herbal remedies and supplements · read 2026-08-27
    what it says
    “There's not enough information to say that complementary medicines, herbal remedies and supplements are safe to take with ezetimibe. They're not tested in the same way as pharmacy and prescription medicines.”
  5. HealthHub (Singapore) — Ezetimibe: what is this medication for · read 2026-08-27
    what it says
    “Ezetimibe belongs to the class of medications called cholesterol absorption inhibitors. It works by reducing the cholesterol absorbed in the small intestine … Hence, this medication may reduce your risk for heart attack and stroke.”
  6. HealthHub — Ezetimibe: how should I take this medication · read 2026-08-27
    what it says
    “You may take this medication with or without food. If you are taking cholestyramine or colestipol, take it 4 hours before or 2 hours after ezetimibe.”
  7. HealthHub — Ezetimibe: common side effects · read 2026-08-27
    what it says
    “Stomach disturbances, e.g. diarrhoea, stomach pain; Feeling tired; Joint pain. Inform your healthcare professional if these side-effects do not go away and interfere with your daily life.”
  8. HealthHub — Ezetimibe: rare but serious side effects · read 2026-08-27
    what it says
    “Very rarely, ezetimibe may cause muscle or liver problems … Breakdown of muscles - Unexplained, severe muscle pain that does not go away, muscle weakness/ cramps all over your body or dark tea-coloured urine”
  9. HealthHub — Ezetimibe: what precautions should I take · read 2026-08-27
    what it says
    “You are allergic to this medication or any of the other ingredients … You are pregnant, planning to become pregnant, or breastfeeding. You are taking any other medications, including supplements … You have liver or kidney problems.”
  10. HealthHub — Ezetimibe: what food or medication should I avoid · read 2026-08-27
    what it says
    “Some medications may interact with ezetimibe … Examples include: Other cholesterol-lowering medications (e.g. cholestyramine, gemfibrozil, fenofibrate)”
  11. US FDA label for ZETIA (ezetimibe), section 2 Dosage and Administration, via openFDA (Organon, effective 2025-11-25) · read 2026-08-27
    what it says
    “The recommended dose of ZETIA is 10 mg orally once daily, administered with or without food … Administer ZETIA at least 2 hours before or 4 hours after administration of a bile acid sequestrant.”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.