{"ok":true,"entry":{"slug":"ezetimibe","kind":"medication","name":"ezetimibe","aliases":["Ezetrol"],"brands_sg":["Ezetrol","Lipez","Ezzicad","Ezoleta","Alvotrol"],"class":"cholesterol absorption inhibitor","tags":["heart-bp"],"use_for":"prescribed for high cholesterol — a doctor decides","use_after":"fda label: 10 mg once daily, with or without food","use_duration":null,"take_with":"water · fda: 2 h before or 4 h after a bile acid binder","pros":["healthhub: may reduce heart attack and stroke risk","fda label: one 10 mg dose, no titration steps","healthhub: with or without food"],"cons":["healthhub: diarrhoea, stomach pain, tiredness","healthhub: very rarely muscle or liver problems","nhs: little information on herbal supplements"],"dose_note":"the us fda label for zetia states 'The recommended dose of ZETIA is 10 mg orally once daily, administered with or without food' — the label gives one adult dose rather than a range and names no higher maximum anywhere in its dosage section. it also says to 'Administer ZETIA at least 2 hours before or 4 hours after administration of a bile acid sequestrant'. every ezetimibe product on the sg register is a 10 mg tablet. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver or kidney problems (healthhub)","pregnancy, planning one, or breastfeeding (healthhub)","an allergy to ezetimibe or any ingredient in it (healthhub)","healthhub: other medicines, supplements and herbal remedies flagged first"],"clashes":[{"src":["hh_eze_howto","fda_zetia_dose"],"note":"healthhub: spacing of 4 hours before or 2 hours after ezetimibe; fda: at least 2 hours before or 4 hours after the sequestrant","with":"cholestyramine, colestipol and other bile acid binders"},{"src":["hh_eze_avoid","nhs_eze_mix"],"note":"healthhub and nhs both list other cholesterol-lowering medicines as interacting","with":"fibrates such as gemfibrozil, fenofibrate or bezafibrate"},{"src":["nhs_eze_mix"],"note":"nhs: tell a doctor if you are taking it before starting ezetimibe","with":"ciclosporin"},{"src":["nhs_eze_mix"],"note":"nhs lists these among medicines that can affect the way ezetimibe works","with":"warfarin and other clot-prevention medicines"},{"src":["nhs_eze_herbs"],"note":"nhs: not enough information to say they are safe with ezetimibe","with":"herbal remedies and supplements"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 31 ezetimibe-containing products carry Forensicclassification 'Prescription Only'; 8 are single-ingredient (ATC C10AX09), every one a 10 mg tablet — SIN12375P EZETROL · SIN15740P LIPEZ · SIN16429P EZZICAD · SIN16422P EZOLETA · SIN15245P ALVOTROL.","accessed":"2026-08-27"},{"id":"nhs_eze_about","url":"https://www.nhs.uk/medicines/ezetimibe/","label":"NHS Medicines A-Z — Ezetimibe (index page)","quote":"Ezetimibe: a medicine used to treat high blood cholesterol … Brand name: Ezetrol. Find out how ezetimibe treats high blood cholesterol and how to take it.","accessed":"2026-08-27"},{"id":"nhs_eze_mix","url":"https://www.nhs.uk/medicines/ezetimibe/taking-ezetimibe-with-other-medicines-and-herbal-supplements/","label":"NHS Medicines A-Z — Taking ezetimibe with other medicines and herbal supplements","quote":"ciclosporin, a medicine used to treat psoriasis or after an organ transplant; medicines used to prevent blood clots, such as warfarin; other medicines used for lowering cholesterol (this does not include statins), such as colestyramine or bezafibrate","accessed":"2026-08-27"},{"id":"nhs_eze_herbs","url":"https://www.nhs.uk/medicines/ezetimibe/taking-ezetimibe-with-other-medicines-and-herbal-supplements/","label":"NHS Medicines A-Z — Mixing ezetimibe with herbal remedies and supplements","quote":"There's not enough information to say that complementary medicines, herbal remedies and supplements are safe to take with ezetimibe. They're not tested in the same way as pharmacy and prescription medicines.","accessed":"2026-08-27"},{"id":"hh_eze_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ezetimibe","label":"HealthHub (Singapore) — Ezetimibe: what is this medication for","quote":"Ezetimibe belongs to the class of medications called cholesterol absorption inhibitors. It works by reducing the cholesterol absorbed in the small intestine … Hence, this medication may reduce your risk for heart attack and stroke.","accessed":"2026-08-27"},{"id":"hh_eze_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ezetimibe","label":"HealthHub — Ezetimibe: how should I take this medication","quote":"You may take this medication with or without food. If you are taking cholestyramine or colestipol, take it 4 hours before or 2 hours after ezetimibe.","accessed":"2026-08-27"},{"id":"hh_eze_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ezetimibe","label":"HealthHub — Ezetimibe: common side effects","quote":"Stomach disturbances, e.g. diarrhoea, stomach pain; Feeling tired; Joint pain. Inform your healthcare professional if these side-effects do not go away and interfere with your daily life.","accessed":"2026-08-27"},{"id":"hh_eze_serious","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ezetimibe","label":"HealthHub — Ezetimibe: rare but serious side effects","quote":"Very rarely, ezetimibe may cause muscle or liver problems … Breakdown of muscles - Unexplained, severe muscle pain that does not go away, muscle weakness/ cramps all over your body or dark tea-coloured urine","accessed":"2026-08-27"},{"id":"hh_eze_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ezetimibe","label":"HealthHub — Ezetimibe: what precautions should I take","quote":"You are allergic to this medication or any of the other ingredients … You are pregnant, planning to become pregnant, or breastfeeding. You are taking any other medications, including supplements … You have liver or kidney problems.","accessed":"2026-08-27"},{"id":"hh_eze_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ezetimibe","label":"HealthHub — Ezetimibe: what food or medication should I avoid","quote":"Some medications may interact with ezetimibe … Examples include: Other cholesterol-lowering medications (e.g. cholestyramine, gemfibrozil, fenofibrate)","accessed":"2026-08-27"},{"id":"fda_zetia_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ZETIA%22&limit=1","label":"US FDA label for ZETIA (ezetimibe), section 2 Dosage and Administration, via openFDA (Organon, effective 2025-11-25)","quote":"The recommended dose of ZETIA is 10 mg orally once daily, administered with or without food … Administer ZETIA at least 2 hours before or 4 hours after administration of a bile acid sequestrant.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}