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Estradiol

Medication oestrogen hormonal
Aka: oestradiol, Estrofem, Climara
Brands seen in Singapore: Estrofem, Progynova, Divigel, Oestrogel, Vagifem
Not medical advice. Check with your doctor or pharmacist before you start, stop or change the timing of anything you take.
How to use
What it’s for
Prescribed for menopause symptoms and bone thinning
When to take
NHS: tablets, gel or spray once a day, SAMe time daily
Take with
Water · NHS: swallowed with a drink, SAMe time each day
Pros & cons
Pros
  • NHS: for hot flushes, low mood, vaginal dryness
  • NHS: also helps prevent weakening bones
  • NHS: tablets, patches, gel or spray forms
Cons
  • NHS: headaches, breast tenderness, vaginal bleeding
  • Hh: hrt raises blood clot and breast cancer risk
  • NHS: with a womb, a progestogen is needed too
Sources
  1. HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally) · read 2026-08-27
    what it says
    “All 7 single-ingredient estradiol products carry Forensicclassification 'Prescription Only' — SIN09922P ESTROFEM TABLET 1 mg · SIN04456P PROGYNOVA TABLET 2 mg · SIN11642P DIVIGEL · SIN06503P OESTROGEL 0.06% · SIN14877P VAGIFEM VAGINAL TABLET 10MCG”
  2. NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: about · read 2026-08-27
    what it says
    “The type of oestrogen most commonly used in HRT is known as estradiol … It's used to treat symptoms of the menopause. It also helps prevent weakening bones (osteoporosis) … Oestrogen is only available on prescription.”
  3. NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: key facts · read 2026-08-27
    what it says
    “Common side effects include headaches, breast tenderness and vaginal bleeding, but these usually improve in the first few months of treatment … HRT can take up to 3 months to work fully to improve your symptoms.”
  4. NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: womb lining and progestogen · read 2026-08-27
    what it says
    “Taking oestrogen can thicken your womb lining, which slightly increases the risk of womb cancer. If you still have your womb, you'll need to also take a progestogen medicine to protect your womb”
  5. NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: dosage and how to take it · read 2026-08-27
    what it says
    “Oestrogen (estradiol) tablets come in strengths of 1mg or 2mg. You take them once a day … Swallow the tablets with a drink of water. Try to take them at the same time each day.”
  6. HealthHub (National Medication Information workgroup, SG) — Hormone Replacement Therapy (cyclic combined HRT, e.g. Progyluton): rare but serious side effects · read 2026-08-27
    what it says
    “Taking HRT increases a woman's risk of developing blood clots and breast cancer. However, these are rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation.”
  7. HealthHub — Hormone Replacement Therapy: what precautions should I take · read 2026-08-27
    what it says
    “You have a history of or current medical conditions such as liver problems, stroke, heart disease, blood clots, migraine headaches, epilepsy, diabetes mellitus or cancer. You are going for a surgery. You may need to stop taking HRT”
  8. HealthHub — Hormone Replacement Therapy: what food or medication should I avoid · read 2026-08-27
    what it says
    “Some medications including antibiotics, antifungals and St John's wort may affect how HRT works or be affected by HRT.”
  9. US FDA label for estradiol tablets USP, Dosage & Administration, via openFDA (Northwind Health Company, effective 2026-01-01) · read 2026-08-27
    what it says
    “The usual initial dosage range is 1 to 2 mg daily of estradiol adjusted as necessary to control presenting symptoms … Use of estrogen … should be with the lowest effective dose and for the shortest duration”
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Updated 2026-08-29. Every line above traces to a numbered source. Kozen-X is not a medical device and does not give medical advice. It lists what published sources have written down — nothing more. A pair not listed is unrecorded, not cleared. Before you start, stop or re-time anything, talk to your doctor or pharmacist.