{"ok":true,"entry":{"slug":"estradiol","kind":"medication","name":"estradiol","aliases":["oestradiol","Estrofem","Climara"],"brands_sg":["Estrofem","Progynova","Divigel","Oestrogel","Vagifem"],"class":"oestrogen","tags":["hormonal"],"use_for":"prescribed for menopause symptoms and bone thinning","use_after":"nhs: tablets, gel or spray once a day, same time daily","use_duration":null,"take_with":"water · nhs: swallowed with a drink, same time each day","pros":["nhs: for hot flushes, low mood, vaginal dryness","nhs: also helps prevent weakening bones","nhs: tablets, patches, gel or spray forms"],"cons":["nhs: headaches, breast tenderness, vaginal bleeding","hh: hrt raises blood clot and breast cancer risk","nhs: with a womb, a progestogen is needed too"],"dose_note":"the us fda label for estradiol tablets states 'The usual initial dosage range is 1 to 2 mg daily of estradiol adjusted as necessary to control presenting symptoms' and that use of estrogen 'should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman' — it sets no single numeric daily maximum for menopause use, and the higher figures it carries (10 mg three times daily) belong to palliative breast-cancer use, not menopause. nhs: 'Oestrogen (estradiol) tablets come in strengths of 1mg or 2mg. You take them once a day.' sg-registered estradiol tablets are estrofem 1 mg and 2 mg and progynova 2 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver problems, stroke, heart disease or blood clots (healthhub)","migraine, epilepsy, diabetes or a cancer history (healthhub)","an intact womb — nhs: a progestogen is needed as well","surgery ahead — healthhub: hrt may need a pause first"],"clashes":[{"src":["hh_hrt_interactions"],"note":"healthhub: may affect how hrt works or be affected by hrt","with":"some antibiotics and antifungals"},{"src":["hh_hrt_interactions"],"note":"healthhub lists it among products that may affect hrt","with":"st john's wort"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 7 single-ingredient estradiol products carry Forensicclassification 'Prescription Only' — SIN09922P ESTROFEM TABLET 1 mg · SIN04456P PROGYNOVA TABLET 2 mg · SIN11642P DIVIGEL · SIN06503P OESTROGEL 0.06% · SIN14877P VAGIFEM VAGINAL TABLET 10MCG","accessed":"2026-08-27"},{"id":"nhs_oest_about","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/oestrogen-tablets-patches-gel-and-spray/about-oestrogen-tablets-patches-gel-and-spray/","label":"NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: about","quote":"The type of oestrogen most commonly used in HRT is known as estradiol … It's used to treat symptoms of the menopause. It also helps prevent weakening bones (osteoporosis) … Oestrogen is only available on prescription.","accessed":"2026-08-27"},{"id":"nhs_oest_key","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/oestrogen-tablets-patches-gel-and-spray/about-oestrogen-tablets-patches-gel-and-spray/","label":"NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: key facts","quote":"Common side effects include headaches, breast tenderness and vaginal bleeding, but these usually improve in the first few months of treatment … HRT can take up to 3 months to work fully to improve your symptoms.","accessed":"2026-08-27"},{"id":"nhs_oest_womb","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/oestrogen-tablets-patches-gel-and-spray/about-oestrogen-tablets-patches-gel-and-spray/","label":"NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: womb lining and progestogen","quote":"Taking oestrogen can thicken your womb lining, which slightly increases the risk of womb cancer. If you still have your womb, you'll need to also take a progestogen medicine to protect your womb","accessed":"2026-08-27"},{"id":"nhs_oest_dose","url":"https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/oestrogen-tablets-patches-gel-and-spray/how-and-when-to-take-or-use-oestrogen-tablets-patches-gel-and-spray/","label":"NHS Medicines A-Z — Oestrogen tablets, patches, gel and spray: dosage and how to take it","quote":"Oestrogen (estradiol) tablets come in strengths of 1mg or 2mg. You take them once a day … Swallow the tablets with a drink of water. Try to take them at the same time each day.","accessed":"2026-08-27"},{"id":"hh_hrt_risks","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hormone-replacement-therapy","label":"HealthHub (National Medication Information workgroup, SG) — Hormone Replacement Therapy (cyclic combined HRT, e.g. Progyluton): rare but serious side effects","quote":"Taking HRT increases a woman's risk of developing blood clots and breast cancer. However, these are rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation.","accessed":"2026-08-27"},{"id":"hh_hrt_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hormone-replacement-therapy","label":"HealthHub — Hormone Replacement Therapy: what precautions should I take","quote":"You have a history of or current medical conditions such as liver problems, stroke, heart disease, blood clots, migraine headaches, epilepsy, diabetes mellitus or cancer. You are going for a surgery. You may need to stop taking HRT","accessed":"2026-08-27"},{"id":"hh_hrt_interactions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/hormone-replacement-therapy","label":"HealthHub — Hormone Replacement Therapy: what food or medication should I avoid","quote":"Some medications including antibiotics, antifungals and St John's wort may affect how HRT works or be affected by HRT.","accessed":"2026-08-27"},{"id":"fda_estradiol_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22ESTRADIOL%22+AND+openfda.route:%22ORAL%22&limit=1","label":"US FDA label for estradiol tablets USP, Dosage & Administration, via openFDA (Northwind Health Company, effective 2026-01-01)","quote":"The usual initial dosage range is 1 to 2 mg daily of estradiol adjusted as necessary to control presenting symptoms … Use of estrogen … should be with the lowest effective dose and for the shortest duration","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}